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| | 2,4-Difluoro-3-iodoaniline Basic information |
| Product Name: | 2,4-Difluoro-3-iodoaniline | | Synonyms: | 2,4-Difluoro-3-iodoaniline;Benzenamine, 2,4-difluoro-3-iodo-;HE-CHEMICAL 0400806;2,4-difluoro-3-iodoaniline - [AC77843];2, 6-dichloro-3-bromoaniline | | CAS: | 1437316-91-0 | | MF: | C6H4F2IN | | MW: | 255 | | EINECS: | | | Product Categories: | | | Mol File: | 1437316-91-0.mol |  |
| | 2,4-Difluoro-3-iodoaniline Chemical Properties |
| Boiling point | 266.7±40.0 °C(Predicted) | | density | 2.086±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C, protect from light | | pka | 2.30±0.10(Predicted) | | Appearance | Off-white to light brown Solid |
| | 2,4-Difluoro-3-iodoaniline Usage And Synthesis |
| Uses | 2,4-Difluoro-3-iodoaniline is used in the synthetic preparation of purine derivatives that are protein kinase modulators useful in treatment and prevention of protein kinase-mediated diseases. | | Synthesis | General procedure for the synthesis of 2,4-difluoro-3-iodoaniline from 1,3-difluoro-2-iodo-4-nitrobenzene: To a solution of concentrated hydrochloric acid (4 mL) of 1,3-difluoro-2-iodo-4-nitrobenzene (1.14 g, 4 mmol) was added anhydrous stannous chloride (2.71 g, 12 mmol), and the reaction mixture was heated to 50°C and kept for 1 hour. After completion of the reaction, the mixture was diluted with water, neutralized with 5% aqueous sodium hydroxide solution to pH=9, and then extracted with dichloromethane. The organic phase was washed with saturated saline, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 2,4-difluoro-3-iodoaniline (0.93 g, 91% yield).1H NMR (CDCl3): δ 6.70-6.93 (2H, m), 6.65 (2H, br). | | References | [1] Patent: WO2013/71865, 2013, A1. Location in patent: Page/Page column 57
[2] Patent: CN103102349, 2017, B. Location in patent: Paragraph 0501-0503 |
| | 2,4-Difluoro-3-iodoaniline Preparation Products And Raw materials |
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