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| | Ald-PEG1-t-butyl ester Basic information |
| Product Name: | Ald-PEG1-t-butyl ester | | Synonyms: | Ald-PEG1-t-butyl ester;tert-butyl 3-(3-oxopropoxy)propanoate;Ald-PEG1-C2-Boc;Propanoic acid, 3-(3-oxopropoxy)-, 1,1-dimethylethyl ester | | CAS: | 2100306-48-5 | | MF: | C10H18O4 | | MW: | 202.25 | | EINECS: | | | Product Categories: | | | Mol File: | 2100306-48-5.mol |  |
| | Ald-PEG1-t-butyl ester Chemical Properties |
| Boiling point | 284.8±15.0 °C(Predicted) | | density | 1.007±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DCM, DMF |
| | Ald-PEG1-t-butyl ester Usage And Synthesis |
| Description | Ald-PEG1-t-butyl ester can react with hydrazide and aminooxy groups which are commonly used in biomolecular probes for labeling and crosslinking carbonyls (oxidized carbohydrates). The t-butyl ester can be removed under acidic conditions for further conjugation. | | Uses | Ald-PEG1-C2-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Ald-PEG1-t-butyl ester Preparation Products And Raw materials |
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