6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid

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6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid manufacturers

6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Basic information

Product Name:	6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid
Synonyms:	6-METHYL-2-(4-METHYLPHENYL)IMIDAZO[1,2-A]-PYRIDINE-3-ACETIC ACID;6-methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid;(6-METHYL-2-P-TOLYL-IMIDAZO[1,2-A]PYRIDIN-3-YL)-ACETIC ACID;zolpidic acid/6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetic acid;6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]-;6-methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetic acid (Zolpidic acid);6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-aceticacid(ForZolpidem);2-(4-Methylphenyl)-6-methylimidazole[1,2-a]-pyridine-3-acetic Acid
CAS:	189005-44-5
MF:	C17H16N2O2
MW:	280.32
EINECS:	606-162-4
Product Categories:	Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocyclic Compounds
Mol File:	189005-44-5.mol

6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Chemical Properties

Melting point	243-245°C
density	1.22±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form	solid
pka	2.87±0.10(Predicted)
color	Yellow
Major Application	pharmaceutical small molecule
CAS DataBase Reference	189005-44-5(CAS DataBase Reference)

Safety Information

HS Code

2933399990

MSDS Information

6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Usage And Synthesis

Chemical Properties	Off-White to Pale Beige Solid
Uses	An intermediate in the synthesis of Zolpidem.
Synthesis	82626-48-0 189005-44-5 Example 1a Synthesis of 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetic acid: zolpidem (8.0 g, 26.0 mmol) was dissolved in 6N hydrochloric acid (80 mL) at 0°C and protected by argon with magnetic stirring. The reaction mixture was heated to reflux for 18 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the pH was adjusted to 6.5 by slowly adding 20% sodium hydroxide solution.The precipitated white solid was collected by vacuum filtration to afford the target product, 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetic acid (6.9 g, 94% yield), as a white solid.1H NMR (DMSO-d6) δ 2.30 ( s, 3H), 2.35 (s, 3H), 3.94 (s, 2H), 7.10 (d, J = 9.1 Hz, 1H), 7.25 (d, J = 7.8 Hz, 2H), 7.48 (d, J = 9.1 Hz, 1H), 7.72 (d, J = 7.8 Hz, 2H), 8.18 (s, 1H).13C NMR (100 MHz, DMSO-d6) δ 18.4, 21.4, 30.8, 114.8, 116.6, 121.6, 122.9, 127.9, 128.2, 129.8, 132.4, 137.3, 143.0, 143.5, 171.8.
References	[1] Patent: WO2005/44818, 2005, A2. Location in patent: Page/Page column 18

6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Tag:6-Methyl-2-(4-methylphenyl)imidazol[1,2-a]-pyridine-3-acetic acid(189005-44-5) Related Product Information

6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine Triphenyltin acetate 1-Methylimidazole 2,6-Lutidine 4-Methylpyridine Pyridine 2,4,6-Collidine Ethyl 2-(Chlorosulfonyl)acetate Imidazole Azamethiphos Bensulfuron methyl Kresoxim-methyl Methyl 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetate Tolyloyl propionamide Thiophanate-methyl 6-Methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine-3-acetamide Methyl Zolpidem tartrate Impurity 6