化合物L-655708
| 中文名称 | 化合物L-655708 |
|---|---|
| 中文同义词 | (S)-7-甲氧基-9-氧代-11,12,13,13A-四氢-9H-9H-咪唑并[1,5-A]吡咯并[2,1-C][1,4]苯二氮-1-羧酸乙酯;化合物L-655708;L-655,708,苯二氮卓类反向激动剂;(S)-7-甲氧基-9-氧代-11,12,13,13A-四氢-9H-苯并[E]咪唑并[5,1-C]吡咯并[1,2-A][1,4]二氮杂卓-1-羧酸乙酯;化合物L-655708,10 MM DMSO 溶液;L-655708试剂;L-655708试剂 |
| 英文名称 | L-655,708 |
| 英文同义词 | ETHYL (S)-11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLATE;L-655,708;11,12,13,13A-TETRAHYDRO-7-METHOXY-9-OXO-9H-IMIDAZO[1,5-A]PYRROLO[2,1-C][1,4]BENZODIAZEPINE-1-CARBOXYLIC ACID, ETHYL ESTER;11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1.5-a]pyrrolo[2.1-c][1.4]benzodiazepine-1-carboxylicacidethylester;Ethyl (S)-11,12,13,13a-Tetrahydro-7-methoxy-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate;9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)- (011-14426_500Mg);9H-IMidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid, 11,12,13,13a-tetrahydro-7-Methoxy-9-oxo-, ethyl ester, (13aS)-;(S)-ethyl 7-methoxy-9-oxo-11,12,13,13a- tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate |
| CAS号 | 130477-52-0 |
| 分子式 | C18H19N3O4 |
| 分子量 | 341.36 |
| EINECS号 | |
| 相关类别 | GABA/Glycine receptor |
| Mol文件 | 130477-52-0.mol |
| 结构式 |  |
化合物L-655708 性质
| 熔点 | 175-176 °C |
|---|---|
| 沸点 | 584.4±50.0 °C(Predicted) |
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 储存条件 | Desiccate at +4°C |
| 溶解度 | 二甲基亚砜：6 mg/毫升 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 1.49±0.20(Predicted) |
| 颜色 | 白色至黄色 |
| InChI | 1S/C18H19N3O4/c1-3-25-18(23)15-16-14-5-4-8-20(14)17(22)12-9-11(24-2)6-7-13(12)21(16)10-19-15/h6-7,9-10,14H,3-5,8H2,1-2H3/t14-/m0/s1 |
| InChIKey | YKYOQIXTECBVBB-AWEZNQCLSA-N |
| SMILES | CCOC(=O)c1ncn2-c3ccc(OC)cc3C(=O)N4CCCC4c12 |
L-655708 是有效的, 选择性 GABAA 受体反向激动剂 (Ki=0.45 nM)。
L655708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 orα6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.
L-655708 at 0.7 mg/kg, administered intraperitoneally, would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1, α2, and α3 subunit-containing GABAA receptors and no significant off-target behavioral effects, such as sedation and motor impairment.
安全信息
| WGK Germany | 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
|---|---|
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-14426 | 130477-52-0 L-655708 | 130477-52-0 | 5mg | 880元 |
| 2025/12/22 | HY-14426 | 130477-52-0 L-655708 | 130477-52-0 | 10mM * 1mLin DMSO | 968元 |