H-Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt

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H-Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt Basic information
Product Name:H-Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt
Synonyms:TFLLRAMIDE TRIFLUOROACETATE SALT;L-Threonyl-L-phenylalanyl-L-leucyl-L-leucyl- L-argininamide trifluoroacetate salt;TFLLR-NH2 trifluoroacetate salt;Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt;H-Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt
CAS:
MF:C33H54F3N9O8
MW:761.83
EINECS:
Product Categories:
Mol File:Mol File
H-Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt Structure
H-Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt Chemical Properties
storage temp. -20°C
solubility DMF: 5 mg/ml
DMSO: 10 mg/ml
Ethanol: 0.5 mg/mlPBS (pH 7.2): 3 mg/ml
form lyophilized powder
color white to tan
Safety Information
WGK Germany 3
MSDS Information
H-Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt Usage And Synthesis
UsesTFLLR-NH2 trifluoroacetate salt has been used as a protease-activated receptor-1 (PAR-1) agonist to study its effects on hippocampal CA1 pyramidal neurons and Swell1 knock out mice (cKO).
Biochem/physiol ActionsTFLLR-NH2 is a protease-activated receptor (PARs) agonist which is more selective to PAR-1 than SFLLRN-NH2. Protease-activated receptors (PARs) are present on various organs including, plateles, mast cell, gallblader, oesophagus etc, and regulate various physiological processes including human platelet aggregation, vascular contraction/relaxation, and an increase in endothelial permeability. Recent papers indicated that PAR′s are also involved in sensory processing. Specificly PAR ligands enhance glutamatergic excitatory transmission in substantia gelatinosa (SG) neurons of adult rat spinal cord slices.
References[1] L. D. GARAVILLA. Agonists of proteinase‐activated receptor 1 induce plasma extravasation by a neurogenic mechanism[J]. British Journal of Pharmacology, 2001, 133 1. DOI: 10.1038/sj.bjp.0704152
[2] ATSUFUMI KAWABATA. The PAR-1-activating peptide attenuates carrageenan-induced hyperalgesia in rats[J]. Peptides, 2002, 23 6: Pages 1181-1183. DOI: 10.1016/s0196-9781(02)00053-0
H-Thr-Phe-Leu-Leu-Arg-NH2 trifluoroacetate salt Preparation Products And Raw materials
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