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| | 4'-FLUORO-BIPHENYL-4-CARBOXYLIC ACID Basic information |
| | 4'-FLUORO-BIPHENYL-4-CARBOXYLIC ACID Chemical Properties |
| Melting point | 235-240 °C | | Boiling point | 369.4±25.0 °C(Predicted) | | density | 1.261±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 4.14±0.10(Predicted) | | form | Solid | | color | White to Off-White | | CAS DataBase Reference | 5731-10-2(CAS DataBase Reference) |
| | 4'-FLUORO-BIPHENYL-4-CARBOXYLIC ACID Usage And Synthesis |
| Uses | 4-(4-Fluorophenyl)benzoic acid (Compoud 6) can bind to Bcl-2 with a KD value of 400 μM. 4-(4-Fluorophenyl)benzoic acid can be used to develope Bcl-2 selective anti-cancer agent[1]. | | References | [1] Petros AM, et al. Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6587-91. DOI:10.1016/j.bmcl.2010.09.033 |
| | 4'-FLUORO-BIPHENYL-4-CARBOXYLIC ACID Preparation Products And Raw materials |
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