3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide

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3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide manufacturers

  • MC-1353
  • MC-1353 pictures
  • $1980.00
  • 2026-06-01
  • CAS:676599-90-9
  • Purity:
  • Supply Ability: 10g
3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide Basic information
Product Name:3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide
Synonyms:APHA COMPOUND 8;(E)-N-hydroxy-3-(1-Methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl)acrylaMide;2-Propenamide, N-hydroxy-3-[1-methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl]-;APHA-8;Aroyl pyrrole hydroxy amide #8;MC 1353;MC1353;MC-1353
CAS:676599-90-9
MF:C16H16N2O3
MW:284.31
EINECS:
Product Categories:Histone Deacetylase (HDAC) inhibitor.
Mol File:676599-90-9.mol
3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide Structure
3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide Chemical Properties
storage temp. 2-8°C
solubility DMSO: 10 mg/mL, soluble
form solid
InChI1S/C16H16N2O3/c1-18-11-13(10-14(18)7-8-16(20)17-21)15(19)9-12-5-3-2-4-6-12/h2-8,10-11,21H,9H2,1H3,(H,17,20)/b8-7+
InChIKeyUFQOXIMRSMFQRI-BQYQJAHWSA-N
SMILESCn1cc(cc1\C=C\C(=O)NO)C(=O)Cc2ccccc2
Safety Information
Hazard Codes Xn
Risk Statements 22-41-43
Safety Statements 26-36/37/39
WGK Germany 2
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
Eye Dam. 1
Skin Sens. 1
MSDS Information
ProviderLanguage
SigmaAldrich English
3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide Usage And Synthesis
DescriptionAPHA compound 8 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 3.7, 7.4, 0.42, and 2.8 μM for HDAC1, -2, -3, and -8, respectively) as well as class II HDACs (IC50s = 3.1, 0.1, 3.1, and 4.2 μM for HDAC4, -6, -7, and -10, respectively). It is selective for class I and II HDACs over class III HDACs (IC50s = >30 μM for SIRT1, SIRT2, and SIRT3) and the histone acetyltransferase PCAF (IC50 = >30 μM). At 48 hours post-infection, APHA compound 8 increases replication of oncolytic herpes simplex virus (oHSV) in MDA-MB-231 and 4T1 breast cancer cells when used prior to viral infection at concentrations of 10 and 50 μM.
UsesHDAC-IN-69 (Compound 2) is a derivative of an HDAC inhibitor with inhibitory activity targeting maize histone deacetylase HD2[1].
IC 50HD2
References[1] Ragno R, et al. 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies. J Med Chem. 2004 Mar 11;47(6):1351-9. DOI:10.1021/jm031036f
3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide Preparation Products And Raw materials
Tag:3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide(676599-90-9) Related Product Information
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