- Cynaroside
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- $32.00 / 1mg
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2025-09-08
- CAS:5373-11-5
- Min. Order:
- Purity: 99.73%
- Supply Ability: 10g
- Cynaroside
-
- $0.00 / 10g
-
2025-09-08
- CAS:5373-11-5
- Min. Order: 10g
- Purity: 98%
- Supply Ability: 2
- Cynaroside
-
- $0.00 / 1KG
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2025-06-27
- CAS:5373-11-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 500000kg
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| | Cynaroside Basic information | | Effects |
| | Cynaroside Chemical Properties |
| Melting point | 256～258℃ | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | Boiling point | 838.1±65.0 °C(Predicted) | | density | 1.713±0.06 g/cm3(Predicted) | | pKa | 6.10±0.40(Predicted) | | form | Solid | | color | Yellow to Very Dark Yellow | | Stability: | Hygroscopic | | InChI | InChI=1/C21H20O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-6,16,18-25,27-29H,7H2/t16-,18-,19+,20-,21-/s3 | | InChIKey | PEFNSGRTCBGNAN-QNDFHXLGSA-N | | SMILES | C1(C2=CC=C(O)C(O)=C2)OC2=C(C(O)=CC(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)=C2)C(=O)C=1 |&1:17,18,20,22,24,r| | | LogP | -0.090 (est) | | CAS DataBase Reference | 5373-11-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | DJ3009400 | | HS Code | 29389090 |
| | Cynaroside Usage And Synthesis |
| Effects | Luteolin has a strong bactericidal effect on the respiratory tract, and it is the main active ingredient in the treatment of bronchitis in Qinglan, a unique medicinal material in Xinjiang. Lowers the role of cholesterol in atherosclerosis and enhances capillary relaxation. | | Description | Luteolin-7-O-glucoside is a flavonoid that has been found in many Chinese herbs with diverse biological activities. It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury. Luteoloside blocks 3C protease activity (IC50 = 0.36 mM) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC50 = 0.43 mM). It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg. Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod . | | Chemical Properties | Off-white powder | | Uses | Luteolin 7-Glucoside is a strong antioxidant ant radical scavenger. Used in cancer prevention. | | Definition | ChEBI: A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. | | in vivo | Cynaroside (i.p.; 5mg/kg) reduces binding of PKM2 to hypoxia-inducible factor-1α (HIF-1α) by abolishing translocation of PKM2 to the nucleus and promoting PKM2 tetramer formation, as well as suppressing phosphorylation of PKM2 at Y105[2]. | Animal Model: | Mice model of sepsis[2] | | Dosage: | 5mg/kg | | Administration: | Cynaroside (i.p.; 5mg/kg) | | Result: | Inhibited PKM2 dimer formation in liver of septic mice. |
| | References | [1] ZHANTU LIU. Luteoloside attenuates anoxia/reoxygenation-induced cardiomyocytes injury via mitochondrial pathway mediated by 14-3-3η protein.[J]. Phytotherapy Research, 2018, 32 6: 1126-1134. DOI: 10.1002/ptr.6053
[2] ZEYU CAO. Luteoloside Acts as 3C Protease Inhibitor of Enterovirus 71 In Vitro.[J]. PLoS ONE, 2016, 11 1: e0148693. DOI: 10.1371/journal.pone.0148693
[3] SHAO-HUA FAN. Luteoloside suppresses proliferation and metastasis of hepatocellular carcinoma cells by inhibition of NLRP3 inflammasome.[J]. PLoS ONE, 2014: e89961. DOI: 10.1371/journal.pone.0089961
[4] R PALOMBO. Luteolin-7-glucoside inhibits IL-22/STAT3 pathway, reducing proliferation, acanthosis, and inflammation in keratinocytes and in mouse psoriatic model[J]. Cell Death & Disease, 2016, 7 8: e2344-e2344. DOI: 10.1038/cddis.2016.201 |
| | Cynaroside Preparation Products And Raw materials |
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