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Rafoxanide

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CAS:22662-39-1
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  • CAS:22662-39-1
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Rafoxanide Basic information
Product Name:Rafoxanide
Synonyms:3’-chloro-4’-(p-chlorophenoxy)-3,5-diiodo-salicylanilid;3’-chloro-4’-(p-chlorophenoxy)-3,5-diiodosalicylanilide;bovanide;duofas;flukanide;Rafoxanide 0.1;N-[3-chloro-4-(4-chlorophenoxy)phenyl]-3,5-diiodobenzamide;Disalan
CAS:22662-39-1
MF:C19H11Cl2I2NO3
MW:626.01
EINECS:245-148-9
Product Categories:Used to kill trematode medicine;API;Rafoxanide;22662-39-1
Mol File:22662-39-1.mol
Rafoxanide Structure
Rafoxanide Chemical Properties
Melting point 168-170°
Boiling point 526.6±50.0 °C(Predicted)
density 2.050±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,2-8°C
solubility Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
pka6.04±0.48(Predicted)
form Solid
color White to Off-White
Merck 14,8097
Major Applicationagriculture
environmental
InChIInChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)
InChIKeyNEMNPWINWMHUMR-UHFFFAOYSA-N
SMILESC(NC1=CC=C(OC2=CC=C(Cl)C=C2)C(Cl)=C1)(=O)C1=CC(I)=CC(I)=C1O
CAS DataBase Reference22662-39-1(CAS DataBase Reference)
Safety Information
WGK Germany 3
RTECS VN7870000
HS Code 2924.29.7790
Storage Class11 - Combustible Solids
MSDS Information
Rafoxanide Usage And Synthesis
Chemical PropertiesWhite to Off-White Solid
UsesRafoxanide is a thyroid hormone receptor.
in vivo

Rafoxanide (7.5 mg/kg, i.p., once every 2 d for 88d) reduces colonic tumorgenesis in Apcmin/+ mice[3].

Animal Model:AOM induced Apcmin/+ mice[3]
Dosage:7.5 mg/kg
Administration:Intraperitoneal injection (i.p.), once every 2 d for 88d
Result:Exerted less number and size of AOM induced lesions in the colon. No significant body weight changes were observed.
Detected adenomas (28.6%), advanced adenomas (67.8%) and adenocarcinoma (3.6%) in control group as adenomas (33.3%), advanced adenomas (25%%) and no obvious lesions(41.6%) were detected in treated group.
Caused increased signal for p-eIF2α, CHOP and cleaved caspase-3 in tumor tissues while these signal in non-tumor colon epithelium were barely detectable.
IC 50Schistosome
Rafoxanide Preparation Products And Raw materials
Raw materials3,5-Diiodosalicylic acid-->3-CHLORO-4-(4-CHLOROPHENOXY)ANILINE-->3,4-Dichloronitrobenzene
Tag:Rafoxanide(22662-39-1) Related Product Information
Salicylaldehyde p-Anisidine o-Anisidine Amiodarone m-Anisidine Amiodarone hydrochloride Iopromide 4-(Trifluoromethoxy)aniline Sodium 4-aminosalicylate dihydrate Fatty amine polyoxyethylene ether Sodium salicylate FLUPOXAM 3-CHLORO-4-HYDROXYACETANILIDE 2-HYDROXY-5-IODO-BENZALDEHYDE 3,5-DIIODOSALICYLALDEHYDE Difluorochloromethane 3-Iodobenzylamine hydrochloride 3-IODOBENZAMIDE