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| | 4-Aminobenzamidine dihydrochloride Basic information |
| | 4-Aminobenzamidine dihydrochloride Chemical Properties |
| Melting point | >300 °C(lit.) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Water | | form | Fine Crystalline Powder | | color | White to yellow | | Sensitive | Hygroscopic | | BRN | 3692927 | | Stability: | Hygroscopic | | InChI | InChI=1S/C7H9N3.2ClH/c8-6-3-1-5(2-4-6)7(9)10;;/h1-4H,8H2,(H3,9,10);2*1H | | InChIKey | GHEHNICLPWTXJC-UHFFFAOYSA-N | | SMILES | C1(C=CC(N)=CC=1)C(=N)N.Cl.Cl | | CAS DataBase Reference | 2498-50-2(CAS DataBase Reference) |
| | 4-Aminobenzamidine dihydrochloride Usage And Synthesis |
| Chemical Properties | white to yellowish fine crystalline powder | | Uses | 4-Aminobenzamidine dihydrochloride is a synthetic diamidine derivative that acts as a urokinase inhibitor as well as trypsin inhibitor. It is used as a ligand in affinity chromatography for purification and immobilization of enzymes. | | Application | 4-Aminobenzamidine dihydrochloride can be used to synthesize:
Orally active fibrinogen receptor antagonists based on benzamidines.
Benzamidine derivatives that are selective and potent serine protease inhibitors.
Novel pyrrolo [3,2-c] quinolines that are structural analogs of topoisomerase inhibitors such as coralyne and fagaronine.
Synthesis of a selective inhibitor of PRMT1 (SKLB-639) | | Preparation | 4-Aminobenzamididine dihydrochloride is obtained by cyanation, addition, amination and reduction of 4-nitrobenzoic acid. | | Definition | ChEBI: P-Aminobenzamidine dihydrochloride is an organic molecular entity. | | Synthesis | In a three-necked flask equipped with a reflux condenser tube and a mechanical stirring device, 15.0 g of 4-nitrobenzenecarboximidamide (IV) prepared from Example 2, 20 mL of acetic acid, 45 mL of water, and 45 mL of ethanol (V water: V ethanol=1:1) were added, and the reaction was stirred and refluxed at 60° C. until complete dissolution. Subsequently, 20.3 g of iron powder (n4-nitrobenzenecarboximidamide IV: n iron powder = 1:4) was added to the reaction system, and the reaction was warmed up to 80 °C and continued to be stirred and refluxed for 4 hours. After completion of the reaction, it was filtered while hot. The filtrate was adjusted to pH 11~12 with 20% NaOH solution, at which time a large amount of flocculent precipitation was generated, and after filtration, the filtrate was adjusted to pH 1~2 with concentrated hydrochloric acid. the solution was concentrated until the crystals precipitated, and the resulting crystals were dried in vacuum at 100 ℃ to obtain 17.9 g of 4-nitrobenzenecarboximidamide dihydrochloride (I), as a white solid with 94.7% yield and 99.51% HPLC purity. | | References | [1] Patent: CN104163778, 2016, B. Location in patent: Paragraph 0056; 0057 |
| | 4-Aminobenzamidine dihydrochloride Preparation Products And Raw materials |
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