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| | 2,3-DICHLORO-5-NITROPYRIDINE Basic information | | Uses |
| Product Name: | 2,3-DICHLORO-5-NITROPYRIDINE | | Synonyms: | 2,3-DICHLORO-5-NITROPYRIDINE;2,3-Dichloro-5-nitropyridine 97%;2,3-Dichloro-5-nitropyridine;2,3-Dichloro-5-nitropyridine ,97%;2,3-dichloro-5-nitropyridiMe;2,3-Dichloro-5-nitropyridine>;Pyridine, 2,3-dichloro-5-nitro-;2,3-DICHLORO-5-NITROPYRIDINE ISO 9001：2015 REACH | | CAS: | 22353-40-8 | | MF: | C5H2Cl2N2O2 | | MW: | 192.99 | | EINECS: | 200-258-5 | | Product Categories: | Building Blocks;C5;C5 to C6;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyridine series;Boronic Acid;Pyridines;Pyridine | | Mol File: | 22353-40-8.mol |  |
| | 2,3-DICHLORO-5-NITROPYRIDINE Chemical Properties |
| Melting point | 51-56℃ | | Boiling point | 256°C(lit.) | | density | 1.629±0.06 g/cm3(Predicted) | | Fp | >110°C | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | soluble in Methanol | | pka | -4.99±0.10(Predicted) | | form | powder to crystal | | color | White to Light yellow | | InChI | InChI=1S/C5H2Cl2N2O2/c6-4-1-3(9(10)11)2-8-5(4)7/h1-2H | | InChIKey | XLPDVAVQKGDHNO-UHFFFAOYSA-N | | SMILES | C1(Cl)=NC=C([N+]([O-])=O)C=C1Cl | | CAS DataBase Reference | 22353-40-8(CAS DataBase Reference) |
| Hazard Codes | Xi,T | | Risk Statements | 36/37/38-43-41-37/38-25 | | Safety Statements | 26-36/37/39-45-39 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 1 | | HazardClass | IRRITANT | | PackingGroup | Ⅲ | | HS Code | 29333990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 2,3-DICHLORO-5-NITROPYRIDINE Usage And Synthesis |
| Uses | 5-Nitro-2,3-Dichloropyridine is an important fine chemical intermediate, widely used in the pharmaceutical and pesticide fields. | | Chemical Properties | Light yellow Cryst | | Synthesis | Quinoline (48.5 mL, 0.41 mol) was slowly added to phosphorous trichloride (164.0 mL, 1.75 mol) at 0 °C and under nitrogen protection. Subsequently, 5-nitro-2-hydroxy-3-chloropyridine (204 mg, 1.17 mmol) was added to this stirred mixture. The reaction mixture was heated to 120 °C and maintained for 2 hours. After completion of the reaction, it was cooled to 0 °C and the reaction was quenched by the addition of ice water. The precipitate was collected by filtration, washed with plenty of water and dried to give 2,3-dichloro-5-nitropyridine. Yield: 220 g (97%). Melting point: 53 °C. 1H NMR (300 MHz, DMSO-d6): δ 9.16 (d, 1H, J = 2.4 Hz), 8.94 (d, 1H, J = 2.4 Hz). 13C NMR (300 MHz, DMSO-d6): δ 158.69, 137.36, 132.51, 130.13, 124.39. mass spectra ( electrospray ionization): m/z 193 ([M+H]+). | | References | [1] Synthesis, 1990, # 6, p. 499 - 501
[2] European Journal of Medicinal Chemistry, 2012, vol. 58, p. 355 - 360
[3] Patent: WO2013/117963, 2013, A1. Location in patent: Page/Page column 21
[4] Patent: WO2014/207508, 2014, A1. Location in patent: Page/Page column 55
[5] Roczniki Chemii, 1968, vol. 42, p. 2079,2084 |
| | 2,3-DICHLORO-5-NITROPYRIDINE Preparation Products And Raw materials |
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