SPHINGOMYELINASE

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SPHINGOMYELINASE Basic information
Product Name:SPHINGOMYELINASE
Synonyms:EC 3.1.4.12;SPHINGOMYELINASE;SPHINGOMYELINASE, STAPHYLOCOCCUS AUREUS;SPHINGOMYELIN CHOLINE PHOSPHOHYDROLASE;SPHINGOMYELIN PHOSPHODIESTERASE;sphingomyelinase from human placenta;Sphingomyelinase C;SPHINGOMYELINASE FROM STAPHYLOCOCCUS*AUR EUS
CAS:9031-54-3
MF:
MW:0
EINECS:232-869-9
Product Categories:
Mol File:Mol File
SPHINGOMYELINASE Structure
SPHINGOMYELINASE Chemical Properties
storage temp. 2-8°C
form lyophilized powder
color White to off-white
biological sourceStaphylococcus aureus
Specific Activity100-300units/mg protein (Lowry)
Safety Information
Hazard Codes B
Safety Statements 23-24/25
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsSkin Sens. 1
MSDS Information
ProviderLanguage
SigmaAldrich English
SPHINGOMYELINASE Usage And Synthesis
Usessphingomyelinase is a fluid that can enhance the skin’s moistureretention properties.
UsesSphingomyelinase from Bacillus cereus has been used:
  • in the measurement of membrane capacitance in brain slices
  • for testing and confirming its silkworm-killing activity
  • in enzyme activity assay and for elucidating its effect on hydrolysis of sphingomyelin in complex lipid mixtures

UsesSphingomyelinase from Staphylococcus aureus has been used to:
  • induce neurotoxicity in rat cortical cultures to study the protective effects of minocycline
  • determine the concentration of sphingomyelin from serum samples
  • enhance sphingomyelinase activity to study PARK9-mediated exosome biogenesis

General DescriptionSphingomyelinase from Bacillus cereus (Bc-Smase) is a Mg2+-containing metalloenzyme. Bacillus cereus sphingomyelinase induces hemolysis of sheep erythrocytes.
Biochem/physiol ActionsInitiates the formation of sphingomyelin-based second messengers. Activates MAPK (mitogen-activated protein kinase) and SAPKs (stress-activated protein kinases); generates ceramide from sphingomyelin.
SPHINGOMYELINASE Preparation Products And Raw materials
Tag:SPHINGOMYELINASE(9031-54-3) Related Product Information
SPHINGOMYELIN Tris(2,4-pentanedionato)chroMiuM(III) Cupric acetylacetonate Ethyl isocyanoacetate SALCOMINE Tosylmethyl isocyanide Benzyl isocyanide COBALT(II) ACETYLACETONATE Aluminum acetylacetonate N-Butylisocyanide Methyl isocyanoacetate 1,1,3,3-Tetramethylbutyl isocyanide tert-Butyl isocyanide Phenylselenol 2,4-Pentanedione, silver derivative Dichloro(ethylenediamine)platinum(II) Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)dysprosium(III) Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)europium(III)