DYNORPHIN A (1-10)
| 中文名称 | DYNORPHIN A (1-10) |
|---|---|
| 中文同义词 | DYNORPHIN A (1-10), PORCINE,YGGFLRRIRP;强啡肽A(1-10);强啡肽A(1-10)、 DYNORPHIN A (1-10);猪强啡肽A(1-10) |
| 英文名称 | H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH |
| 英文同义词 | YGGFLRRIRP;TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO;dynorphin A, porcine, fragment 1-10;H-TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-OH;DYNORPHIN A (1-10), PORCINE;dynorphin A fragment 1-10 porcine*sequence;DYNORPHIN A (1-10) SYNTHETIC >97% OPIOID AGONIST;Porcine dynorphin A(1-10) |
| CAS号 | 79994-24-4 |
| 分子式 | C57H91N19O12 |
| 分子量 | 1234.45 |
| EINECS号 | |
| 相关类别 | 多肽;peptide |
| Mol文件 | 79994-24-4.mol |
| 结构式 |  |
DYNORPHIN A (1-10) 性质
| 储存条件 | -15°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 序列 | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro |
κ-opioid receptor
NMDA receptor
Dynorphin A (1-10) binds in the transmembrane domain of the κ-receptor. The non-opioid actions of various forms of Dynorphin A (DynA) are examined on N-methyl-D-aspartate (NMDA) receptor channels in isolated rat trigeminal neurons using the whole-cell patch recording technique. All the dynorphins tested blocked NMDA-activated currents. The blocking actions are voltage-independent. The IC 50 is 42.0 μM for DynA(1-10). To determine if shorter dynorphins have the similar blocking property, we examined the action of DynA(1-10) at different membrane potentials. DynA(1-10) blocks I NMDA to a similar extent as the membrane potentials changed from -80 to +60 mV. Thus, despite a 160-fold difference in the apparent affinities, DynA(1-32) and DynA(1-10) both exert voltage-independent actions on NMDA receptors.