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| | 2,2,2-Trifluoroethylamine hydrochloride Basic information |
| Product Name: | 2,2,2-Trifluoroethylamine hydrochloride | | Synonyms: | 2,2,2-Trifluoroethyla;2,2,2-trifluoroethan-1-aMine chloride;2,2,2-trifluoroethanaminium chloride;2,2,2-TrifluoroethylaMine Hydrochloride, 97+%;TAF;TRIFLUOROETHYLAMINE HYDROCHLORIDE;2,2,2-TRIFLUOROETHYLAMINE HYDROCHLORIDE;2,2,2-TRIFLUORO-ETHYL-AMMONIUM CHLORIDE | | CAS: | 373-88-6 | | MF: | C2H5ClF3N | | MW: | 135.52 | | EINECS: | 206-771-1 | | Product Categories: | | | Mol File: | 373-88-6.mol |  |
| | 2,2,2-Trifluoroethylamine hydrochloride Chemical Properties |
| Melting point | 220-222 °C (subl.)(lit.) | | density | 1,24g/cm | | refractive index | 1,3-1,302 | | storage temp. | Inert atmosphere,Room Temperature | | form | powder to crystal | | color | White to Light yellow to Light orange | | Water Solubility | It is Soluble in 0.7 to water, but soluble in ethanol and chloroform, slightly soluble in benzene, hardly soluble in ether. | | Sensitive | Hygroscopic | | BRN | 3652103 | | InChI | InChI=1S/C2H4F3N.ClH/c3-2(4,5)1-6;/h1,6H2;1H | | InChIKey | ZTUJDPKOHPKRMO-UHFFFAOYSA-N | | SMILES | C(F)(F)(F)CN.Cl | | CAS DataBase Reference | 373-88-6(CAS DataBase Reference) | | EPA Substance Registry System | Ethanamine, 2,2,2-trifluoro-, hydrochloride (373-88-6) |
| Hazard Codes | Xn,T,Xi | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 36/37-24/25-36-26 | | WGK Germany | 3 | | RTECS | KS0250000 | | F | 3-10-21 | | Hazard Note | Hygroscopic/Toxic | | TSCA | TSCA listed | | HazardClass | IRRITANT | | PackingGroup | III | | HS Code | 29211990 | | Toxicity | LD50 unr-mus: 476 mg/kg 11FYAN 3,81,63 |
| | 2,2,2-Trifluoroethylamine hydrochloride Usage And Synthesis |
| Chemical Properties | WHITE TO LIGHT YELLOW CRYSTALLINE POWDER | | Uses | 2,2,2-Trifluoroethylamine Hydrochloride is a reagent in the synthesis of arachidonylethanolamide analogs. These show affinity for CB1 and CB2 cannabinoid receptors. | | Safety Profile | Moderately toxic by unspecifiedroute. When heated to decomposition it emits very toxicfumes of F??, NOx, and HCl. | | Synthesis | General procedure for the synthesis of 2,2,2-trifluoroethylamine hydrochloride from 2,2,2-trifluoroethylamine: 100 g of ethanol and 33 g of 2,2,2-trifluoroethylamine were added to a triple-necked flask, and 35 g of saturated hydrochloric acid solution was added slowly and dropwise at temperatures lower than 25°C. The reaction system was then brought up to 50°C and maintained there for 1 hour. After the dropwise addition, the temperature of the reaction system was raised to 50 °C and maintained for 1 hour. Subsequently, the temperature of the reaction solution was controlled to be 45±5°C under a vacuum of 0.98 MPa and a decompression distillation was carried out for 5 hours to remove water and ethanol. Finally 43.5 g of 2,2,2-trifluoroethylamine hydrochloride was obtained in 96.30% yield. The resulting product was a white powdery crystalline solid with 0.13% water. | | References | [1] Patent: CN105801428, 2016, A. Location in patent: Paragraph 0016; 0017 |
| | 2,2,2-Trifluoroethylamine hydrochloride Preparation Products And Raw materials |
| Raw materials | 2,2,2-TRIFLUOROETHYLAMINE-->Ethanol-->Water-->Hydrochloric acid | | Preparation Products | 1-Bromo-4-(2,2,2-trifluoroethyl)benzene-->Benzenamine, 3-methoxy-N-(2,2,2-trifluoroethyl)--->Urea, N-methyl-N'-(2,2,2-trifluoroethyl)--->2-chloro-N-(2,2,2-trifluoroethyl)acetamide-->Benzenamine, 3-methyl-N-(2,2,2-trifluoroethyl)--->Benzenamine, 3-chloro-N-(2,2,2-trifluoroethyl)--->4-bromo-N-(2,2,2-trifluoroethyl)aniline |
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