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| | 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE Basic information |
| | 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE Chemical Properties |
| Melting point | 169-171 °C(lit.) | | Boiling point | 389.8±17.0 °C(Predicted) | | density | 1.389±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 3.95±0.10(Predicted) | | form | Powder | | color | White to off-white | | λmax | 232nm(phosphate buffer sol.)(lit.) | | BRN | 153889 | | InChI | 1S/C9H7ClN2S/c10-7-3-1-6(2-4-7)8-5-13-9(11)12-8/h1-5H,(H2,11,12) | | InChIKey | DWGWNNCHJPKZNC-UHFFFAOYSA-N | | SMILES | Nc1nc(cs1)-c2ccc(Cl)cc2 | | LogP | 3.411 (est) | | CAS DataBase Reference | 2103-99-3(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-36/37/39 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | XJ1026732 | | HazardClass | IRRITANT | | PackingGroup | III | | HS Code | 29341000 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powde | | Uses | 2-Amino-4-(4-chlorophenyl)thiazole was used in the preparation of 2-chloroacetamido-4-(4-chlorophenyl)thiazole. | | Synthesis | GENERAL METHOD: A mixture of thiourea (1.2 mmol) and α-bromo-4-chloroacetophenone (1 mmol) in ethanol (2 mL) was stirred and reacted at 70 °C for 1 hour. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water, filtered to collect the precipitate precipitated, and dried to obtain the target product 2-amino-4-(4-chlorophenyl)thiazole. The product yields and physical properties were as follows: [6a (99% yield), white solid, melting point 150-152 °C (literature value 26: 149-150 °C); 6b (100% yield), white solid, melting point 162-165 °C (literature value 26: 163-164 °C); 6c (0.236 g, 93% yield), white solid, melting point 179-181 °C (literature value 26: 180-181 °C); 6d (98% yield), white solid, melting point 203.6-204.2 °C (literature value 28/22: 204.0-204.5 °C); 6e (94% yield), bright yellow solid, melting point 287-288 °C (literature values 26,27: 285-286 °C); 6f (100% yield), white solid, melting point 172-174°C (literature values 29-31: 172°C). | | References | [1] Arkivoc, 2018, vol. 2018, # 7, p. 110 - 118
[2] Chinese Chemical Letters, 2014, vol. 25, # 1, p. 172 - 175
[3] Research on Chemical Intermediates, 2015, vol. 41, # 11, p. 8099 - 8109
[4] Molecules, 2017, vol. 22, # 5,
[5] Synthetic Communications, 2009, vol. 39, # 16, p. 2895 - 2906 |
| | 2-AMINO-4-(4-CHLOROPHENYL)THIAZOLE Preparation Products And Raw materials |
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