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| | 5-Hydroxyisophthalic acid Basic information |
| | 5-Hydroxyisophthalic acid Chemical Properties |
| Melting point | 298-302 °C (lit.) | | Boiling point | 235.5°C (rough estimate) | | density | 1.3293 (rough estimate) | | vapor pressure | 0Pa at 25℃ | | refractive index | 1.4330 (estimate) | | storage temp. | Store below +30°C. | | solubility | 0.6g/l | | form | Powder | | pka | 3.41±0.10(Predicted) | | color | White to slightly yellow | | PH | <7 (H2O, 20℃) | | Water Solubility | 0.6g/L(15 ºC) | | BRN | 2693561 | | InChI | 1S/C8H6O5/c9-6-2-4(7(10)11)1-5(3-6)8(12)13/h1-3,9H,(H,10,11)(H,12,13) | | InChIKey | QNVNLUSHGRBCLO-UHFFFAOYSA-N | | Dissociation constant | 0-0 at 23℃ | | CAS DataBase Reference | 618-83-7(CAS DataBase Reference) | | EPA Substance Registry System | 5-Hydoxyisophthalic acid (618-83-7) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39-24/25-36 | | WGK Germany | 2 | | RTECS | CZ4280000 | | TSCA | TSCA listed | | HS Code | 29182990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5-Hydroxyisophthalic acid Usage And Synthesis |
| Chemical Properties | white to slightly yellow powder | | Uses | 5-Hydroxyisophthalic Acid is used as a reagent in the synthesis of silver carboxylate metal organic framework (MOF) complexes. 5-Hydroxyisophthalic Acid is also used as the starting material in the synthesis of N,NтАЩ-Bis(2,3-dihydroxypropyl)-5-[(N-(2-hydroxyethyl)carbamoyl)methoxy]-2,4,6-triiodoisophthalamide (B426310); a compound related to Ioversol( I737000) which is a nonionic, low osmolality, radiographic contrast agent. | | General Description | The hydrothermal reaction of 5-hydroxyisophthalic acid, Co(II)/Cu(II) and dipyridophenazine, that forms two 3D chiral coordination polymers, was studied. | | Synthesis | The general procedure for the synthesis of 5-hydroxyisophthalic acid from dimethyl 5-hydroxyisophthalate was as follows: dimethyl 5-hydroxyisophthalate (40 g, 19.03 mmol) was dissolved in THF (10 mL), followed by the addition of aqueous lithium hydroxide (20 mL, 2 M). The reaction mixture was stirred at 40 °C overnight. Upon completion of the reaction, THF was removed by distillation under reduced pressure. the pH of the remaining aqueous solution was adjusted to about 2 with 6N hydrochloric acid to precipitate the product. The precipitated 5-hydroxyisophthalic acid was collected by filtration and dried in a vacuum oven to give 20 g of white solid product in 58% yield. | | References | [1] Patent: WO2010/78449, 2010, A2. Location in patent: Page/Page column 317 |
| | 5-Hydroxyisophthalic acid Preparation Products And Raw materials |
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