| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Acetylsalicylic Acid-d4
CAS:97781-16-3
Package:50Mg,5Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:2-ACETOXYBENZOIC-3,4,5,6-D4 ACID
CAS:97781-16-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| | 2-ACETOXYBENZOIC-3,4,5,6-D4 ACID Basic information |
| | 2-ACETOXYBENZOIC-3,4,5,6-D4 ACID Chemical Properties |
| Melting point | 131-1330C | | storage temp. | Refrigerator | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | color | White to Off-White |
| | 2-ACETOXYBENZOIC-3,4,5,6-D4 ACID Usage And Synthesis |
| Description | Aspirin-d4 is intended for use as an internal standard for the quantification of aspirin by GC- or LC-MS. Aspirin is a non-selective, irreversible COX inhibitor. The IC50 values for ovine COX-1 and -2 are 0.75 and 1.25 mM, respectively. Aspirin acetylates COX-1 at Ser530 and COX-2 at Ser516 resulting in irreversible enzyme inhibition. | | Chemical Properties | 2-ACETOXYBENZOIC-3,4,5,6-D4 ACID is Off-White Solid | | Uses | Analgesic; antipyretic; anti-inflammatory; antithrombotic | | Uses | Labeled Aspirin, intended for use as an internal standard for the quantification of Aspirin by GC- or LC-mass spectrometry. | | References | [1] BYRON CRYER MD Mark F M. Cyclooxygenase-1 and Cyclooxygenase-2 Selectivity of Widely Used Nonsteroidal Anti-Inflammatory Drugs[J]. American Journal of Medicine, 1998, 104 5: Pages 413-421. DOI: 10.1016/s0002-9343(98)00091-6
[2] JENNIFER L. JOHNSON . Purification and Characterization of Prostaglandin H Synthase-2 from Sheep Placental Cotyledons[J]. Archives of biochemistry and biophysics, 1995, 324 1: Pages 26-34. DOI: 10.1006/abbi.1995.9934
[3] J PAPP. Antiplatelet effect of acetylsalicylic acid, metamizole and their combination - in vitro and in vivo comparisons.[J]. Clinical hemorheology and microcirculation, 2014, 56 1: 1-12. DOI: 10.3233/ch-2012-1636
[4] SHAWN N WHITEHEAD. Effects of triflusal and aspirin in a rat model of cerebral ischemia.[J]. Stroke, 2007, 38 2: 381-387. DOI: 10.1161/01.str.0000254464.05561.72
[5] T. CYRUS. Effect of Low-Dose Aspirin on Vascular Inflammation, Plaque Stability, and Atherogenesis in Low-Density Lipoprotein Receptor–Deficient Mice[J]. Circulation: Journal of the American Heart Association, 2002, 88 1: 1282-1287. DOI: 10.1161/01.cir.0000027816.54430.96 |
| | 2-ACETOXYBENZOIC-3,4,5,6-D4 ACID Preparation Products And Raw materials |
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