|
|
| | Milnacipran Hydrochloride Basic information |
| Product Name: | Milnacipran Hydrochloride | | Synonyms: | F 2207;IXEL;(1R,2S)-REL-2-(AMINOMETHYL)-N,N-DIETHYL-1-PHENYLCYCLOPROPANECARBOXAMIDE HYDROCHLORIDE;(1R,2S)-REL-2-(AMINOMETHYL)-N,N-DIMETHYL-1-PHENYLCYCLOPROPANECARBOXAMIDE HYDROCHLORIDE;Milnacipran hydrochloride solution;F 2207, Midalcipran, Toledomin, (1R,2S)-rel-2-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropanecarboxamide monohydrochloride;rel-2α*-(Aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1α*-carboxamide·hydrochloride;rac Milnacipran Hydrochloride | | CAS: | 101152-94-7 | | MF: | C15H23ClN2O | | MW: | 282.81 | | EINECS: | 620-477-4 | | Product Categories: | NEGGRAM;Amines;Aromatics;Chiral Reagents;Antibiotic Explorer;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 101152-94-7.mol |  |
| | Milnacipran Hydrochloride Chemical Properties |
| Melting point | 179-1810C | | Fp | 9℃ | | storage temp. | 2-8°C | | solubility | H2O: 19 mg/mL | | form | solid | | color | white | | Water Solubility | H2O: 19mg/mL | | Merck | 14,6194 | | InChI | InChI=1/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/s3 | | InChIKey | XNCDYJFPRPDERF-DPKVYHSMNA-N | | SMILES | [C@@]1(C(=O)N(CC)CC)(C[C@H]1CN)C1C=CC=CC=1.Cl |&1:0,9,r| | | CAS DataBase Reference | 101152-94-7(CAS DataBase Reference) |
| Hazard Codes | Xn,T,F | | Risk Statements | 22-39/23/24/25-23/24/25-11 | | Safety Statements | 7-16-36/37-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | GZ1014010 | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29242990 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral | | Toxicity | LD50 orally in mice: 237 mg/kg (Bonnaud) |
| | Milnacipran Hydrochloride Usage And Synthesis |
| Chemical Properties | Crystalline Solid | | Uses | Milnacipran Hydrochloride is an antidepressant. A selective norepinephrine and serotonin reuptake inhibitor approved for the management of fibromyalgia. | | Definition | ChEBI: Milnacipran hydrochloride is a member of acetamides. | | General Description | Milnacipran Hydrochloride, sold under the brand names Savella, Ixel, Dalcipran, or Toledomin, is a serotonin-norepinephrine reuptake inhibitor (SNRI) used in the treatment of depression. In 2009, the US Food and Drug Administration (FDA) approved milnacipran for management of the chronic pain disorder fibromyalgia, making it only the third drug approved in the US for this indication besides duloxetine and pregabalin. | | Biological Activity | Orally active 5-HT and noradrenalin re-uptake inhibitor (SNRI) (IC 50 values are 203 and 100 nM respectively) that displays no affinity at a range of other receptors. Causes adaptive changes to α 1 -adrenergic and 5-HT 2A serotonergic systems when administered repeatedly. Exhibits antidepressive and antinociceptive activities in vivo . | | Biochem/physiol Actions | Serotonin and norepinephrine reuptake inhibitor (SNRI) | | storage | +4°C |
| | Milnacipran Hydrochloride Preparation Products And Raw materials |
|