2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole Suppliers list

Company Name:	Shanghai Yifei Biotechnology Co. , Ltd.
Tel:	021-65675885 18964387627
Email:	customer_service@efebio.com

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole Basic information

Product Name:	2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole
Synonyms:	2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole;1,3,4-Oxadiazole, 2,5-bis[3-(2-oxiranylmethoxy)phenyl]-;GAPDH inhibitor compound F8;GAPDH-IN-1
CAS:	252212-58-1
MF:	C20H18N2O5
MW:	366.37
EINECS:
Product Categories:
Mol File:	252212-58-1.mol

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole Chemical Properties

Boiling point	584.4±58.0 °C(Predicted)
density	1.318±0.06 g/cm3(Predicted)
solubility	Acetonitrile: Slightly soluble: 0.1-1 mg/ml
pka	-5.20±0.45(Predicted)

Safety Information

MSDS Information

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole Usage And Synthesis

Uses	GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity). GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD+, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine[1].
References	[1] Jung Y, et al. Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe. ACS Chem Biol. 2022 Feb 18;17(2):340-347. DOI:10.1021/acschembio.1c00824

2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole Preparation Products And Raw materials

Tag:2,5-bis[3-(oxiran-2-ylmethoxy)phenyl]-1,3,4-oxadiazole(252212-58-1) Related Product Information

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