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021-67680335 13052188602 |
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| Product Name: | GDF-3, HUMAN | | Synonyms: | HUMAN GROWTH AND DIFFERENTIATION FACTOR-3;HUMAN GDF-3;HUMAN PRO248;GDF-3, HUMAN;HUMAN UNQ222;Growth Diffrentiation Factor-3;Vgr-2 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![GDF-3, HUMAN Structure]() |
| | GDF-3, HUMAN Chemical Properties |
| storage temp. | -20°C | | form | lyophilized | | color | white to off-white | | biological source | human |
| | GDF-3, HUMAN Usage And Synthesis |
| Uses | GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type-2 diabetes. Recombinant human GDF-3 contains 114 amino acids polypeptide chains | | Biological Activity | GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains. | | Description | GDF3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 124 amino acids and having a total molecular mass of 14.15 kDa.
GDF3 is fused to a 10 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | GDF3 is a member of the TGF-beta superfamily though it does not show similarity pattern of conserved cysteine residues. GDF3 is linked to Vg-1 and human BMP-4. GDF3 transcripts are identified mainly in adult bone marrow, spleen, thymus, and adipose tissue. GDF3 expression is upregulated strongly in high-fat-fed C57Bl/6J FABP4/aP2 null mice, which develop obesity but not the related hyperglycemia or hyperinsulinemia characteristic of type II diabetes. GDF3 expression therefore bonds fatty acid metabolism in adipocytes and the expression of a differentiation regulator belonging to the bone morphogenetic proteins. |
| | GDF-3, HUMAN Preparation Products And Raw materials |
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