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| | 2-(2-Methoxyethoxy)acetic acid Basic information |
| Product Name: | 2-(2-Methoxyethoxy)acetic acid | | Synonyms: | TIMTEC-BB SBB008497;3,6-DIOXAHEPTANOIC ACID;2-(2-METHOXYETHOXY)ACETIC ACID;(2-methoxyethoxy)acetic acid;2-(2-METHOXYETHOXY)ACETIC ACID, TECH.;2-(2-Methoxyethoxy)Acetic;o-(2-methoxyethyl)glycolic acid;(2-Methoxyethoxy)essigsure | | CAS: | 16024-56-9 | | MF: | C5H10O4 | | MW: | 134.13 | | EINECS: | 240-161-6 | | Product Categories: | Heterocyclic Compounds | | Mol File: | 16024-56-9.mol |  |
| | 2-(2-Methoxyethoxy)acetic acid Chemical Properties |
| Boiling point | 245-250 °C (lit.) | | density | 1.18 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.436(lit.) | | Fp | >230 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Chloroform, DMSO, Methanol | | pka | 3.40±0.10(Predicted) | | form | Oil | | color | Clear Colourless | | Water Solubility | Fully miscible in water. | | BRN | 1753567 | | InChI | 1S/C5H10O4/c1-8-2-3-9-4-5(6)7/h2-4H2,1H3,(H,6,7) | | InChIKey | CLLLODNOQBVIMS-UHFFFAOYSA-N | | SMILES | COCCOCC(O)=O | | CAS DataBase Reference | 16024-56-9(CAS DataBase Reference) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 1 | | HazardClass | 8 | | PackingGroup | II | | Storage Class | 8A - Combustible corrosive hazardous materials | | Hazard Classifications | Skin Corr. 1B |
| | 2-(2-Methoxyethoxy)acetic acid Usage And Synthesis |
| Chemical Properties | Colorless to pale yellow liquid | | Uses | 2-(2-Methoxyethoxy)acetic Acid is a urinary metabolite of Diglyme (D446300) that is a reproductive toxin. 2-(2-Methoxyethoxy)acetic Acid can be used as a biomarker of exposure for jet fuel JP-8 workers. | | Synthesis | General procedure for the synthesis of methoxyethoxyacetic acid from 2-methoxyethanol and tert-butyl bromoacetate: 2-methoxyethanol (10 g, 131.4 mmol) and potassium tert-butoxide (17.67 g, 157.68 mmol) were dissolved in 100 mL of tetrahydrofuran (THF). The reaction mixture was heated to 45 °C, maintained for 1 h and then cooled to room temperature. To the above mixture was added tert-butyl bromoacetate (25.63 g, 131.41 mmol) and the reaction was stirred at room temperature for 16 hours. After completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in water. The pH of the aqueous phase was adjusted to 12-12.5 with 1 M sodium hydroxide aqueous solution and stirring was continued for 12-14 hours at room temperature. Subsequently, the pH of the aqueous phase was adjusted with 10% aqueous phosphoric acid solution to 2. The product was extracted with dichloromethane (DCM). The DCM was removed by rotary evaporator to give 2-(2-methoxyethoxy)acetic acid as an oil (4.1 g, 23% yield). | | References | [1] Patent: WO2015/79459, 2015, A1. Location in patent: Paragraph 00261 |
| | 2-(2-Methoxyethoxy)acetic acid Preparation Products And Raw materials |
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