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| | β-Ht 920 dihydrochloride Basic information |
| Product Name: | β-Ht 920 dihydrochloride | | Synonyms: | 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amineDihydrochloride,6-Allyl-2-amino-5,6,7,8-tetrahydro-4;B-HT920dihydrochlorideTalipexole;5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepin-2-amine Dihydrochloride, 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine Dihydrochloride;Talipexole, 5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride;5,6,7,8-Tetrahydro-6-(2-propen-1-yl)-4H-thiazolo[4,5-d] azepin-2-amine dihydrochloride;talipexole hydrochloride;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride;2-Amino-6-allyl-4,5,7,8-tetrahydro-6H-thiazolo(5,4-D)azepin-dihydrochlorid [german] | | CAS: | 36085-73-1 | | MF: | C10H17Cl2N3S | | MW: | 282.23 | | EINECS: | | | Product Categories: | Adrenoceptor;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals | | Mol File: | 36085-73-1.mol |  |
| | β-Ht 920 dihydrochloride Chemical Properties |
| Melting point | 245°C dec. | | storage temp. | Desiccate at RT | | solubility | H2O: >20 mg/mL | | form | solid | | color | off-white |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | RTECS | XJ7050340 |
| | β-Ht 920 dihydrochloride Usage And Synthesis |
| Description | B-HT 920 is a potent agonist of dopamine 2 (D2) receptors (Ki = 5.8 nM) that shows selectivity for D2 over D3 and D4 receptors. It has neuroprotective and regenerative effects in animal models of Parkinson’s disease. B-HT 920 is also an agonist of α2-adrenergic receptors and an antagonist of serotonin-3 (5-HT3; Ki = 0.35 μM) receptors. | | Chemical Properties | B-HT 920 DIHYDROCHLORIDE is Light Yellow Solid | | Uses | B-HT 920 DIHYDROCHLORIDE is an alpha 2-Adrenoceptor and dopamine D2-receptor agonist. Used as an antiparkinson reagent | | Definition | ChEBI: Talipexole dihydrochloride is an azepine. | | Biological Activity | Dopamine D 2 receptor agonist, α 2 -adrenoceptor agonist and 5-HT 3 receptor antagonist. Displays antiParkinsonian activity. | | References | [1] FRANCIS K. MAINA Tiffany A M. Functional Fast Scan Cyclic Voltammetry Assay to Characterize Dopamine D2 and D3 Autoreceptors in the Mouse Striatum[J]. ACS Chemical Neuroscience, 2010, 1 6: 450-462. DOI: 10.1021/cn100003u
[2] RICHARD E. MEWSHAW. New Generation Dopaminergic Agents. 1. Discovery of a Novel Scaffold Which Embraces the D2 Agonist Pharmacophore. StructureActivity Relationships of a Series of 2-(Aminomethyl)chromans[J]. Journal of Medicinal Chemistry, 1997, 40 26: 4235-4256. DOI: 10.1021/jm9703653
[3] G S ROBERTSON. In vivo comparisons of the effects of quinpirole and the putative presynaptic dopaminergic agonists B-HT 920 and SND 919 on striatal dopamine and acetylcholine release.[J]. Journal of Pharmacology and Experimental Therapeutics, 1993, 264 3: 1344-1351.
[4] KITAMURA Y. [Dopaminergic neuroprotection and reconstruction of neural network tiara].[J]. Yakugaku zasshi: Journal of the Pharmaceutical Society of Japan, 2010, 130 10: 1263-1272. DOI: 10.1248/yakushi.130.1263
[5] HIROAKI NISHIO . 5-HT3 receptor blocking properties of the antiparkinsonian agent, talipexole[J]. General Pharmacology-the Vascular System, 1996, 27 5: Pages 779-785. DOI: 10.1016/0306-3623(95)02125-6
[6] DANIEL RICCI Carlos A T. Adrenoceptor Involvement in the Cardiovascular Responses to B-HT 920 in Sinoaortic Denervated Rats[J]. General Pharmacology-the Vascular System, 1999, 32 1: Pages 29-34. DOI: 10.1016/s0306-3623(98)00018-4 |
| | β-Ht 920 dihydrochloride Preparation Products And Raw materials |
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