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| | Bromoacetaldehyde diethyl acetal Basic information |
| | Bromoacetaldehyde diethyl acetal Chemical Properties |
| Boiling point | 66-67 °C18 mm Hg(lit.) | | density | 1.31 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.439(lit.) | | Fp | 125 °F | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Oil | | color | Clear Colourless | | Specific Gravity | 1.310 | | Water Solubility | immiscible | | Sensitive | Moisture Sensitive | | BRN | 635754 | | InChI | 1S/C6H13BrO2/c1-3-8-6(5-7)9-4-2/h6H,3-5H2,1-2H3 | | InChIKey | LILXDMFJXYAKMK-UHFFFAOYSA-N | | SMILES | CCOC(CBr)OCC | | CAS DataBase Reference | 2032-35-1(CAS DataBase Reference) | | NIST Chemistry Reference | Ethane, 2-bromo-1,1-diethoxy-(2032-35-1) | | EPA Substance Registry System | Ethane, 2-bromo-1,1-diethoxy- (2032-35-1) |
| Hazard Codes | Xi,T | | Risk Statements | 10-36-36/38-23-22 | | Safety Statements | 16-26-45-38-37/39-28A-36/37 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | F | 8-9-21 | | Hazard Note | Toxic/Irritant | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29110000 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Inhalation
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2 |
| | Bromoacetaldehyde diethyl acetal Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liqui | | Uses | Synthetic building block1,2 | | Uses | Bromoacetaldehyde diethyl acetal, is used as a synthetic building block. It is mainly used for synthesis of antibiotics such as erythromycin and cephalosporins and to other drugs. It also can be used as pharmaceutical intermediates. Besides, this chemical can be used to pruduce drugs such as methylthio imidazole, chlorpheniramine and others for thyroid. It also acts as a Useful intermediate for the preparation of other -heterosubstituted acetaldehyde acetals. | | Preparation | To a flask containing 118.0 gm (1.0 mole) of diethyl acetal and 55 gm (0.55 mole) of calcium carbonate is dropwise added 55 ml (1.0 mole) of bromine over a 30-45 min period while keeping the reaction temperature at 5°-10°C. The reaction mixture is allowed to stand 24 hr, steam is introduced to dissolve the salts, the oil separated, dried over potassium carbonate, and distilled to afford 61-83 gm (31-42%), b.p. 167°-170°C. The product is further purified by shaking with potassium carbonate and distilling it under reduced pressure, b.p. 48°-49°C (3 mm Hg). The pure acetal is unstable and becomes colored in a few hours and black after several days. However, the crude acetal boiling at 167°-170°C is stable for several months.
 | | General Description | May darken in storage |
| | Bromoacetaldehyde diethyl acetal Preparation Products And Raw materials |
| Raw materials | Bromine-->Vinyl acetate | | Preparation Products | Thianaphthene-->1-Benzofuran-5-carbaldehyde-->BENZOFURAN-5-BORONIC ACID-->3-Bromo-7-(trifluoromethyl)imidazo[1,2-a]pyrimidine-->7-(TRIFLUOROMETHYL)-3-IODOIMIDAZO[1,2-A]PYRIMIDINE-->7-BROMO-3-TRIFLUOROMETHYL-IMIDAZO[1,2-B][1,2,4]TRIAZINE-->1-BENZOFURAN-5-CARBONITRILE-->5-Bromo-1-benzofuran-->BENZO[B]THIOPHEN-5-YL-5-BORONIC ACID-->4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-->5-METHYL-1-BENZOTHIOPHENE-2-CARBALDEHYDE-->5-Methoxybenzofuran-->Pyrrolo[2,3-d]pyrimidin-4-ol-->3,3-Diphenyltetrahydrofuran-2-ylidene(dimethyl)ammonium bromide-->5-Bromo-4-chloro-2-(methylthio)-7H-pyrrolo[2,3-D]pyrimidine ,97%-->6-Bromoimidazo[1,2-a]pyridine-->6-BROMO-BENZO[B]THIOPHENE-->5-Methylindole-->6,8-DIBROMOIMIDAZO[1,2-A]PYRAZINE-->3-(P-CHLOROPHENYL)-3-(2-PYRIDYL)PROPYLALDEHYDE DIETHYL ACETAL-->1,1'-oxybis[2,2-diethoxyethane]-->Chlorphenamine maleate-->(2,2-diethoxyethyl)methylamine |
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