N-Acetylanthranilic acid

N-Acetylanthranilic acid Basic information

Product Name:	N-Acetylanthranilic acid
Synonyms:	2-(acetylamino)-benzoicaci;2-carboxyacetanilide;acetylanthranilicacid;Lappaconiticacid;n-acetylaminobenzoicacid;n-acetyl-anthranilicaci;N-Acetylanthranilic acid~2-Carboxyacetanilide;N-Acetylanthranilic acid;2-Acetamidobenzoic acid
CAS:	89-52-1
MF:	C9H9NO3
MW:	179.17
EINECS:	201-914-4
Product Categories:	Pharmaceutical Intermediate;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;API intermediates
Mol File:	89-52-1.mol

N-Acetylanthranilic acid Chemical Properties

Melting point	184-187 °C(lit.)
Boiling point	311.69°C (rough estimate)
density	1.2822 (rough estimate)
refractive index	1.5600 (estimate)
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 0.5 mg/ml
pka	pK1: 3.63 (25°C)
form	A crystalline solid
Water Solubility	slightly soluble
BRN	880371
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents.
CAS DataBase Reference	89-52-1(CAS DataBase Reference)
EPA Substance Registry System	Benzoic acid, 2-(acetylamino)- (89-52-1)

Safety Information

MSDS Information

N-Acetylanthranilic acid Usage And Synthesis

Description	N-Acetylanthranilic acid (Item No. 18707) is an analytical reference standard categorized as a precursor in the synthesis of methaqualone (Item Nos. 20283 \| 9000636).1 N-Acetylanthranilic Acid is regulated as a List I chemical in the United States. This product is intended for research and forensic applications.WARNING This product is not for human or veterinary use.
Chemical Properties	solid
Definition	ChEBI: An amidobenzoic acid consisting of anthranilic acid carrying an N-acetyl group.
Synthesis Reference(s)	The Journal of Organic Chemistry, 46, p. 4614, 1981 DOI: 10.1021/jo00335a075 Tetrahedron Letters, 23, p. 4473, 1982 DOI: 10.1016/S0040-4039(00)85631-2
Safety Profile	Moderately toxic by ingestion.When heated to decomposition it emits toxic vapors ofNOx.
Purification Methods	Wash the acid with distilled H2O and recrystallise it from aqueous AcOH, dry it and recrystallise again from EtOAc. Also recrystallise it from water or EtOH. UV: max 221, 252 and 305nm (EtOH). The amide crystallises from aqueous EtOH and has m 186-187o and max 218, 252 and 301nm. [Chattaway J Chem Soc 2495 1931, Walker J Am Chem Soc 77 6698 1955, Beilstein 14 H 337, 14 I 540, 14 II 219, 14 III 922.]

N-Acetylanthranilic acid Preparation Products And Raw materials

Raw materials	Anthranilic acid-->3-ethyl-2-Methyl-1H-indole-->N-(2-formylphenyl)acetamide-->METHYL 2-ACETAMIDOBENZOATE-->N,N-DIMETHYLOXAMICACID -->2'-BROMOACETANILIDE-->4'-Bromoacetanilide-->2-Methylindole-3-carboxaldehyde-->2,3-Dimethylindole-->2-Azidobenzoic acid-->2-ACETAMIDO-5-BROMOBENZOIC ACID-->carbon monoxide-->Acetanilide
Preparation Products	METHAQUALONE-->Etaqualone-->2-METHYL-4(3H)-QUINAZOLINONE-->2-Methyl-4H-3,1-benzoxazin-4-one

Tag:N-Acetylanthranilic acid(89-52-1) Related Product Information

4-Acetamidobenzaldehyde 2-ACETAMIDOFLUORENE Methyl anthranilate Ethyl 2-(Chlorosulfonyl)acetate 4-Aminobenzoic acid Glycine Folic acid Citric acid Ascoric Acid N-Acetylanthranilic acid N-(2-CARBOXYPHENYL)PHTHALIMIDE 2-ACETAMIDO-5-BROMOBENZOIC ACID 2-ACETAMIDO-6-CHLOROBENZOIC ACID 5-(OCTADECANOYLAMINO)FLUORESCEIN Anthranilic acid EXO1 N-(4-CARBOXYPHENYL)SUCCINAMIC ACID LAPPACONITINE HYDROBROMIDE

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