3,7-dimethyl-8-quinolin-2-ylsulfanylpurine-2,6-dione manufacturers
- RS-246204
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2026-08-08
- CAS:878451-87-7
- Purity:
- Supply Ability: 10g
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| | 3,7-dimethyl-8-quinolin-2-ylsulfanylpurine-2,6-dione Basic information |
| | 3,7-dimethyl-8-quinolin-2-ylsulfanylpurine-2,6-dione Chemical Properties |
| density | 1.54±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 5 mg/mL (14.73 mM);Water : < 0.1 mg/mL (insoluble) | | pka | 9.43±0.70(Predicted) | | form | Solid | | color | White to light yellow |
| | 3,7-dimethyl-8-quinolin-2-ylsulfanylpurine-2,6-dione Usage And Synthesis |
| Description | RS-246204 is a small molecule R-spondin-1 substitute. It acts by promoting the initial formation and growth of enteroids in the medium without R-spondin-1. | | Uses | RS-246204 is a R-spondin-1 substitute compound that is able initiate small intestinal organoids without the use of the R-spondin-1 protein. | | in vivo | RS-246204 significantly increased BrdU+ cells and body weight in the DSS induced colitis model. These results suggest that RS-246204 activates the R-spondin dependent pathway in Lgr5 stem cells, thereby enhancing proliferation or the anti-apoptotic effect, promoting regeneration of the intestinal epithelium and reducing the disease severity[1]. | | References | [1] Nam MO, et al. Effects of a small molecule R-spondin-1 substitute RS-246204 on a mouse intestinal organoid culture. Oncotarget. 2017 Dec 26;9(5):6356-6368. DOI:10.18632/oncotarget.23721 |
| | 3,7-dimethyl-8-quinolin-2-ylsulfanylpurine-2,6-dione Preparation Products And Raw materials |
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