- MDK-4823
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- $2500.00
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2026-05-21
- CAS:1908414-82-3
- Purity:
- Supply Ability: 10g
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| | LMPTP inhibitor1 Basic information |
| Product Name: | LMPTP inhibitor1 | | Synonyms: | LMPTP inhibitor1;LMPTP INHIBITOR COMPOUND 1;CS-2789;LMPTP inhibitor-Compound 23;MLS-0322825 Cmpd 23;LMW-PTP Inhibitor I;INVIVO-4823;NN-Diethyl-4-[4-[[3-(1-piperidinyl)propyl]amino]-2-quinolinyl]benzamide | | CAS: | 1908414-82-3 | | MF: | C28H36N4O | | MW: | 444.61 | | EINECS: | | | Product Categories: | | | Mol File: | 1908414-82-3.mol |  |
| | LMPTP inhibitor1 Chemical Properties |
| Boiling point | 657.7±55.0 °C(Predicted) | | density | 1.121±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20mg/mL,DMSO: 10mg/mL,Ethanol: 15mg/mL,PBS (pH 7.2): 3mg/mL | | pka | 9.48±0.10(Predicted) |
| | LMPTP inhibitor1 Usage And Synthesis |
| Description | LMW-PTP inhibitor I is an inhibitor of low molecular weight phosphotyrosine protein phosphatase A (LMW-PTPA; IC50 = 0.8 μM). It is selective for LMW-PTPA over a panel of 15 protein tyrosine phosphatases but does inhibit LMW-PTPB activity by greater than 50% at 40 μM. LMW-PTP inhibitor I increases insulin-induced insulin receptor phosphorylation in HepG2 cells when used at a concentration of 10 μM. It improves glucose tolerance and decreases fasting plasma insulin levels in a mouse model of diet-induced obesity when administered at a dose of 50 mg/kg per day. | | Uses | LMPTP inhibitor 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. | | in vivo | LMPTP inhibitor 1 is orally bioavailable, and results in appr 680 nM mean serum concentration after treatment of 0.03% w/w, while treatment with 0.05% w/w results in >3 μM; also reverses diabetes in obese mice. LMPTP inhibitor 1 (0.05% w/w) inhibits LMPTP activity, significantly improves glucose tolerance and decreases fasting insulin levels of diabetic DIO mice, without affecting body weight[1]. | | References | [1] Stanford SM1, et al. Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase. Nat Chem Biol. 2017 Jun;13(6):624-632. DOI:10.1038/nchembio.2344 |
| | LMPTP inhibitor1 Preparation Products And Raw materials |
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