| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
NCT-502 manufacturers
- NCT-502
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- $52.00
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2026-07-14
- CAS:1542213-00-2
- Purity: 99.60%
- Supply Ability: 10g
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| | NCT-502 Basic information |
| Product Name: | NCT-502 | | Synonyms: | NCT-502;1-Piperazinecarbothioamide, N-(4,6-dimethyl-2-pyridinyl)-4-[5-(trifluoromethyl)-2-pyridinyl]-;6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide;N-(4;N-(4,6-dimethylpyridin-2-yl)-4-[5-(trifluoromethyl)pyridin-2-yl]piperazine-1-carbothioamide;NCT 502,inhibit,NCT502,Inhibitor,NCT-502;N-(4,6-dimethylpyridin-2-yl)-4-(5-(trifluoromethyl)pyridin-2-yl)pipera;NCT-502, 10 mM in DMSO | | CAS: | 1542213-00-2 | | MF: | C18H20F3N5S | | MW: | 395.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1542213-00-2.mol |  |
| | NCT-502 Chemical Properties |
| Boiling point | 512.3±60.0 °C(Predicted) | | density | 1.355±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide | | form | solution in methanol. | | pka | 12.95±0.20(Predicted) | | color | Light yellow to yellow |
| | NCT-502 Usage And Synthesis |
| Uses | NCT-502 is a novel inhibitor of human Phosphoglycerate Dehydrogenase (PHGDH). | | Definition | ChEBI: N-(4,6-dimethyl-2-pyridinyl)-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinecarbothioamide is a member of piperazines and a member of pyridines. | | Biological Activity | nct-502 is an inhibitor of 3-phosphoglycerate dehydrogenase (phgdh).serine, a proteinogenic amino acid, is the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. homo sapiens phosphoglycerate dehydrogenase (phgdh) catalyzes the first, rate-limiting step in the canonical pathway of glucose-derived serine synthesis. | | in vitro | nct-502 was identified as an inhibitor of 3-phosphoglycerate dehydrogenase (phgdh), inhibiting serine synthesis from 3-phosphoglycerate in cells. nct-502 was inactive against a panel of other dehydrogenases and showed minimal cross-reactivity in a panel of 168 g-protein-coupled receptors. moreover, in mda-mb-231-phgdh cells, nct-502 treatment could decrease the intracellular serine and glycine concentrations and did not change the concentration of any other amino acid except for aspartate. in addition, nct-502-mediated inhibition of serine synthesis was found to be reversible in cells [1]. | | in vivo | to evaluate the in-vivo activity nct-503, a structurally close analog of nct-502, nod.scid mice bearing mda-mb-231 and mda-mb-468 orthotopic xenografts were treated with vehicle or nct-503. results showed that nct-503 reduced the growth and weight of phgdh-dependent mda-mb-468 xenografts but did not affect those of phgdh-independent mda-mb-231 xenografts. phgdh inhibition caused by nct-503 also selectively increased necrosis in mda-mb-468 but not mda-mb-231 xenografts. importantly, mice treated with nct-503 did not lose weight during the 24-d treatment [1]. | | IC 50 | 3.7 μm | | references | [1] pacold, m. e.,brimacombe, k.r.,chan, s.h., et al. a phgdh inhibitor reveals coordination of serine synthesis and one-carbon unit fate. nature chemical biology 12(6), 452-458 (2016). |
| | NCT-502 Preparation Products And Raw materials |
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