| Company Name: |
Nantong Hi-Future Biotechnology Co., Ltd
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| Tel: |
18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:JTT 551
CAS:776309-04-7
Purity:98%HPLC Package:10mg，100mg，500mg，1g，2g，5g，10mg，More
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JTT-551 manufacturers
- JTT 551
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- $3400.00
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2026-07-27
- CAS:776309-04-7
- Purity:
- Supply Ability: 10g
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| | JTT-551 Basic information |
| Product Name: | JTT-551 | | Synonyms: | JTT-551;JTT-551 sodium
(JTT551;Glycine, N-[[5-(1,1-dimethylethyl)-2-thiazolyl]methyl]-N-[[4-[4-[[4-(1-propylbutyl)phenoxy]methyl]phenyl]-2-thiazolyl]methyl]- | | CAS: | 776309-04-7 | | MF: | C34H43N3O3S2 | | MW: | 605.85 | | EINECS: | | | Product Categories: | | | Mol File: | 776309-04-7.mol |  |
| | JTT-551 Chemical Properties |
| Boiling point | 724.8±60.0 °C(Predicted) | | density | 1.174±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 3.77±0.10(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | JTT-551 Usage And Synthesis |
| Uses | JTT 551 is selective a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with Kis of 0.22 μM and 9.3 μM for PTP1B and TCPTP (T-cell protein tyrosine phosphatase), respectively; JTT 551 can be used in the research of type 2 diabetes mellitus. | | in vivo | JTT 551 (3 mg/kg, 30 mg/kg, p.o.) dose-dependently decreases blood glucose level on Days 7, 14 and 28 in db/db Mice. JTT 551 also significantly reduces triglyceride (TG) level at 30 mg/kg on Day 7 but does not alter insulin and total cholesterol (TC) levels[1]. | | References | [1] Fukuda S, et al. Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551. Diabetes Obes Metab. 2010 Apr;12(4):299-306. DOI:10.1111/j.1463-1326.2009.01162.x |
| | JTT-551 Preparation Products And Raw materials |
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