PV-1115
| 中文名称 | PV-1115 |
|---|---|
| 中文同义词 | 化合物 T24688;化合物 PV-1115 |
| 英文名称 | PV-1115 |
| 英文同义词 | PV-1115;1H-Indole-2-carboxamide, N-[4-[1-[2-(4,5-dihydro-1H-imidazol-2-yl)hydrazinylidene]ethyl]phenyl]-7-nitro- |
| CAS号 | 1093793-10-2 |
| 分子式 | C20H19N7O3 |
| 分子量 | 405.41 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1093793-10-2.mol |
| 结构式 |  |
PV-1115 性质
| 密度 | 1.49±0.1 g/cm3(Predicted) |
|---|---|
| 酸度系数(pKa) | 12.12±0.30(Predicted) |
PV1115 is a potent and highly selective Chk2 inhibitor with an IC50 of 0.14 nM, 66000 nM, >100000 nM for Chk2, Chk1 and RSK2, respectively. PV1115 is situated within the ATP-binding pocket of Chk2.