α-GalCer analog 8 manufacturers
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| | α-GalCer analog 8 Basic information |
| Product Name: | α-GalCer analog 8 | | Synonyms: | α-GalCer analog 8;α-Galactosylceramide analog 8;α-D-Galactopyranoside, (2S,3S,4R)-3,4-dihydroxy-2-(4-tetracosyl-1H-1,2,3-triazol-1-yl)octadecyl;α-GalCer analog 8 (α-Galactosylceramide analog 8) | | CAS: | 922727-14-8 | | MF: | C50H97N3O8 | | MW: | 868.34 | | EINECS: | | | Product Categories: | | | Mol File: | 922727-14-8.mol |  |
| | α-GalCer analog 8 Chemical Properties |
| Boiling point | 928.8±75.0 °C(Predicted) | | density | 1.09±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble | | form | A solid | | pka | 12.92±0.70(Predicted) |
| | α-GalCer analog 8 Usage And Synthesis |
| Description | α-Galactosylceramide analog 8 (α-GalCer analog 8) is a triazole derivative of α-galactosylceramide.1 It increases IL-2 secretion by DN32.D3 NKT hybridoma cells when co-cultured with CD1d-transfected RBL cells pre-loaded with α-GalCer analog 8 at a concentration of 32 ng/ml. α-GalCer analog 8 (32 ng/ml) induces IL-4 secretion to a greater extent than the synthetic α-GalCer KRN 7000 in mouse splenocytes in vitro and in mouse serum following administration of a 1 μg per animal dose, indicating a Th2 response. | | Uses | α-GalCer analog 8 is a triazole derivative of α-Galactosylceramide (HY-102022). α-Galactosylceramide is a synthetic glycolipid with antitumorial and immunostimulatory[1]. | | References | 1. Lee, T., Cho, M., Ko, S.-Y., et al. Synthesis and evaluation of 1,2,3-triazole containing analogues of the immunostimulant α-GalCer J. Med. Chem. 50(3),585-589(2007). |
| | α-GalCer analog 8 Preparation Products And Raw materials |
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