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LY2940094 tartrate manufacturers
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| | LY2940094 tartrate Basic information |
| Product Name: | LY2940094 tartrate | | Synonyms: | LY-2940094;CS-2822;LY-2940094 tartrate;LY-2940094 tartrate，BTRX-246040;(2-(4-((2'-Chloro-4',4'-difluoro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)methyl)-3-methyl-1H-pyrazol-1-yl)pyridin-3-yl)methanol (2R,3R)-2,3-dihydroxysuccinate | | CAS: | 1307245-87-9 | | MF: | C22H23ClF2N4O2S.C4H6O6 | | MW: | 631.05 | | EINECS: | | | Product Categories: | | | Mol File: | 1307245-87-9.mol |  |
| | LY2940094 tartrate Chemical Properties |
| | LY2940094 tartrate Usage And Synthesis |
| Uses | LY2940094 (BTRX-246040) tartrate is a potent, brain penetrant, selective and orally available N/OFQ peptide (NOP) receptor antagonist with high affinity (Ki=0.105 nM) and antagonist potency (Kb=0.166 nM). LY2940094 tartrate reduces Ethanol self-administration and Ethanol seeking in animal models[1]. | | in vivo | LY2940094 (3, 10, or 30 mg/kg; orally daily for 4 days) dose-dependently reduces homecage ethanol self-administration in Indiana Alcohol-Preferring (P) and Marchigian Sardinian Alcohol-Preferring (msP) rats, without affecting food/water intake or locomotor activity[1]. | Animal Model: | Female Alcohol-Preferring (P) rats (250-320 g); Male Marchigian Sardinian Alcohol-Preferring (msP) rats (400-450 g)[1] | | Dosage: | 3, 10, or 30 mg/kg | | Administration: | P.o.; daily for 4 days | | Result: | Reduced homecage ethanol self-administration.
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| | References | [1] Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54. DOI:10.1111/acer.13052 |
| | LY2940094 tartrate Preparation Products And Raw materials |
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