2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide manufacturers
- ML382
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- $41.00
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2026-05-26
- CAS:1646499-97-9
- Purity: 99.79%
- Supply Ability: 10g
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| | 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Basic information |
| Product Name: | 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide | | Synonyms: | 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide;ML 382;Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)-;ML382,Inhibitor,ML 382,nociceptor,pain,injury,DRG,inhibit,neurons,nervous,ML-382;2-cyclopropanesulfonamido-N-(2-ethoxyphenyl)benzamide;ML382, 10 mM in DMSO | | CAS: | 1646499-97-9 | | MF: | C18H20N2O4S | | MW: | 360.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1646499-97-9.mol | ![2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Structure](CAS/20200331/GIF/1646499-97-9.gif) |
| | 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Chemical Properties |
| density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | A solid | | pka | 8.30±0.20(Predicted) | | color | White to off-white | | InChIKey | RCSLEKLNDJJJLF-UHFFFAOYSA-N | | SMILES | O=C(C1=C(C=CC=C1)NS(C2CC2)(=O)=O)NC3=C(C=CC=C3)OCC |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Usage And Synthesis |
| Uses | ML 382 acts as a potent and selective allosteric modulator of MrgX1, used in the stufy to improve the potency and efficacy of anti-chronic pain medicaments. | | Biological Activity | ML382 is a positive allosteric modulator of Mas-related G-protein-coupled receptor X1 (MrgprX1, MrgX1, SNSR4), a G-protein coupled receptor (GPCR) selectively expressed in dorsal root ganglion (DRG) neurons. MrgX1 is believed to be a functional ortholog of mouse MrgC11, which has been shown to be involved in itch and pain. ML382 is selective for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters, with an EC50 value of 190 nm with an Emax value of 148% in the presence of the known ligand BAM8-22. | | in vivo | ML382 (5 μM) significantly increases inhibition of ICa by a low concentration of BAM8–22 (0.5 μM) in DRG neurons from MrgprX1 mice. ML382 enhances the inhibition of spinal synaptic transmission by BAM8-22 in MrgprX1 mice. ML382 (25 μM, 125 μM, and 250 μM; 5 μL; i.th.;) dose-dependently attenuates heat hypersensitivity in MrgprX1 mice. ML382 (lumbar puncture injection; 25 μM, 5 μL) leads to a significant increase in postconditioning time spent in the ML382-paired chamber, compared with the preconditioning value. ML382 inhibits nerve injury-induced ongoing pain in MrgprX1 mice[1]. | | storage | Store at RT |
| | 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide Preparation Products And Raw materials |
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