(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid

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(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid Basic information
Product Name:(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid
Synonyms:(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid;N-Fmoc-N,O-dimethyl-L-serine;(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methoxypropanoic acid;L-Serine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N,O-dimethyl-;Fmoc-?N,?O-?dimethyl-?L-?serine
CAS:1569103-64-5
MF:C20H21NO5
MW:355.38
EINECS:
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Mol File:1569103-64-5.mol
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid Structure
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid Chemical Properties
Boiling point 540.6±50.0 °C(Predicted)
density 1.266±0.06 g/cm3(Predicted)
storage temp. Storage temp. 2-8°C
form Solid
pka3.42±0.10(Predicted)
color White to light yellow
Safety Information
MSDS Information
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid Usage And Synthesis
UsesN-Fmoc-N,O-dimethyl-L-serine is a serine derivative that can be used for coibamide A synthesis. Coibamide A is a marine natural product with potent antiproliferative activity against human cancer cells[1][2].
References[1] Yao G, et al. Efficient Synthesis and Stereochemical Revision of Coibamide A. J Am Chem Soc. 2015 Oct 28;137(42):13488-91. DOI:10.1021/jacs.5b09286
[2] Tranter D, et al. Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins. ACS Chem Biol. 2020 Aug 21;15(8):2125-2136. DOI:10.1021/acschembio.0c00325
(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid Preparation Products And Raw materials
Tag:(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}(methyl)amino)-3-methoxypropanoic acid(1569103-64-5) Related Product Information
N-（(9H-fluoren-9-ylmethoxy)carbonyl）-N-methyl-O-propyl-L-S (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-propoxypropanoic acid Fmoc-2-Amino-5,5,5-F-N-Me-L-Norvaline N-（(9H-fluoren-9-ylmethoxy)carbonyl）-O-(2-hydroxy-2-methyl (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-hydroxypentanoic acid N-（(9H-fluoren-9-ylmethoxy)carbonyl）-O-(3-methylbutyl)-L-S (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-(2-hydroxy-2-methylpropoxy)propanoic acid