MAST CELL DEGRANULATING PEPTIDE

MAST CELL DEGRANULATING PEPTIDE Suppliers list
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Products Intro: Product Name:MAST CELL DEGRANULATING PEPTIDE
CAS:32908-73-9
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Products Intro: Product Name:Mast Cell Degranulating (MCD) Peptide
CAS:32908-73-9
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CAS:32908-73-9
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Products Intro: Product Name:Mast Cell Degranulating (MCD) Peptide Peptide 401
CAS:32908-73-9
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MAST CELL DEGRANULATING PEPTIDE manufacturers

MAST CELL DEGRANULATING PEPTIDE Basic information
Product Name:MAST CELL DEGRANULATING PEPTIDE
Synonyms:H-ILE-LYS-+CYS-ASN-++CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-+CYS-ARG-LYS- ILE-++CYS-GLY-LYS-ASN-NH2;H-ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2;H-ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2 (RANDOM CYCLIZATION);IKCNCKRHVIKPHICRKICGKN-NH2;ILE-LYS-CYS-ASN-CYS-LYS-ARG-HIS-VAL-ILE-LYS-PRO-HIS-ILE-CYS-ARG-LYS-ILE-CYS-GLY-LYS-ASN-NH2;MAST CELL DEGRANULATING PEPTIDE;MAST CELL DEGRANULATING PEPTIDE (APIS MELLIFERA);MAST CELL DEGRANULATING (MCD) PEPTIDE
CAS:32908-73-9
MF:C110H192N40O24S4
MW:2587.24
EINECS:628-471-3
Product Categories:
Mol File:32908-73-9.mol
MAST CELL DEGRANULATING PEPTIDE Structure
MAST CELL DEGRANULATING PEPTIDE Chemical Properties
density 1.50±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility Soluble in DMSO
form Solid
color White to off-white
Safety Information
WGK Germany 3
RTECS OQ5980000
MSDS Information
ProviderLanguage
SigmaAldrich English
MAST CELL DEGRANULATING PEPTIDE Usage And Synthesis
UsesPeptide 401, a potent mast cell degranulating factor from bee venom, suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, and 5-HT).
Biological ActivityPeptide 401 is a potent mast cell degranulation peptide derived from bee venom that inhibits vascular permeability.
in vivo

Peptide 401 substantially inhibits the oedema provoked by subplantar injection of carrageenin or intra-articular injection of turpentine in the rat. The ED 50 of 401 is c. 0.1 mg/kg. The anti-inflammatory effect is assessed by measurement of the increased 125 I-albumin content of an injected site in comparison with an uninjected contralateral site. Peptide 401 also suppresses the increased vascular permeability due to intradermal injection of various smooth muscle spasmogens (histamine, bradykinin, 5-hydroxytryptamine (5-HT), and prostaglandins). Peptide 401 (MCD peptide) contains 22 residues and occurs in the venom of the common European honey bee to the extent of about 2% by weight . It has powerful anti-inflammatory activity (at doses as low as 0.1 mg/kg) in a variety of animal models, ie, hind paw oedema in the rat induced by carrageenin or turpentine, adjuvant arthritis in the rat, and increased skin permeability in the rat resulting from subcut aneous injection of bradykinin, prostaglandin E1 kallikrein, histamine and 5-hydroxytryptamine (5-HT). It has a powerful degranulating effect on mast cells and involves the release of histamine and other pharmacologically active agents.

target< /table>

serotonin

Histamine Receptor

IC 50serotonin; Histamine Receptor
References[1] Hanson JM, et al. Anti-inflammatory property of 401 (MCD-peptide), a peptide from the venom of the bee Apis mellifera (L.). Br J Pharmacol. 1974 Mar;50(3):383-92. DOI:10.1111/j.1476-5381.1974.tb09613.x
[2] Banks BE, et al. Anti-inflammatory activity of bee venom peptide 401 (mast cell degranulating peptide) andcompound 48/80 results from mast cell degranulation in vivo. Br J Pharmacol. 1990 Feb;99(2):350-4. DOI:10.1111/j.1476-5381.1990.tb14707.x
MAST CELL DEGRANULATING PEPTIDE Preparation Products And Raw materials
Tag:MAST CELL DEGRANULATING PEPTIDE(32908-73-9) Related Product Information
3':5'-CYCLIC-NUCLEOTIDE 5'-NUCLEOTIDOHYDROLASE ECHISTATIN PHOSPHOLIPASE A2 MASTOPARAN 17 VAL-ASP-TRP-LYS-LYS-ILE-GLY-GLN-HIS-ILE-LEU-SER-VAL-LEU-NH2 MU-CONOTOXIN GIIIA Desacetylcinobufagin 19-Hydroxybufalin MAS 7 MAST CELL DEGRANULATING PEPTIDE HR-1 MAST CELL DEGRANULATING PEPTIDE HR-2 ENTEROTOXIN STP (E COLI) CHLOROTOXIN SHK NA CYS-GLY MAST CELL DEGRANULATING PEPTIDE MAST CELL DEGRANULATING PEPTIDE

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