2-Fluoropyridine-5-boronic acid pinacol ester manufacturers
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| | 2-Fluoropyridine-5-boronic acid pinacol ester Basic information |
| Product Name: | 2-Fluoropyridine-5-boronic acid pinacol ester | | Synonyms: | 2-Fluoro-5-pyridineboronic acid pinacol ester;2-FLUORO-5-(4 4 5 5-TETRAMETHYL-(1 3 2)&;6-FLUOROPYRIDINE-3-BORONIC ACID, PINACOL ESTER;2-Fluoro-5-pyridineboronic acid pinacol ester, 2-Fluoro-5-(4,4,5,5-tetramethyl-[1,3,2]-dioxaborolan-2-yl)-pyridine;2-Fluoropyridin-5-ylboronic acid pinacol ester;2-Fluoropyridine-5-boronic acid pinacol ester;2-Fluoropyridine-5-boronic acid pinacol ester >=95%;2-Flouropyridine-5-boronic acid pinacol ester | | CAS: | 444120-95-0 | | MF: | C11H15BFNO2 | | MW: | 223.05 | | EINECS: | | | Product Categories: | | | Mol File: | 444120-95-0.mol |  |
| | 2-Fluoropyridine-5-boronic acid pinacol ester Chemical Properties |
| Melting point | 29-33 °C(lit.) | | Boiling point | 304.2±27.0 °C(Predicted) | | density | 1.09±0.1 g/cm3(Predicted) | | Fp | >230 °F | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | -0.44±0.12(Predicted) | | form | powder to lump | | color | White to Light yellow | | InChI | InChI=1S/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-5-6-9(13)14-7-8/h5-7H,1-4H3 | | InChIKey | ZKSRQMCKFLGPQU-UHFFFAOYSA-N | | SMILES | C1(F)=NC=C(B2OC(C)(C)C(C)(C)O2)C=C1 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 2933399990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2-Fluoropyridine-5-boronic acid pinacol ester Usage And Synthesis |
| Uses | 2-Fluoropyridine-5-boronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | | Synthesis | General procedure for the synthesis of 2-fluoro-5-bromopyridine and pinacol ester of bisboronic acid from 2-fluoro-5-bromopyridine and pinacol ester of bisboronic acid: under nitrogen protection, Pd(dppf)Cl2 (4.16 g, 5.68 mmol) was added in a single step to a solution containing 5-bromo-2-fluoro-pyridine (10 g, 56.82 mmol), pinacol ester of bisboronic acid (21.64 g, 85.23 mmol) and potassium acetate (16.73 g, 170.46 mmol) in a solution of dioxane (100 mL). The mixture was stirred at room temperature for 10 minutes and then heated to reflux for 6 hours. Upon completion of the reaction, the solvent was removed by direct evaporation and the residue was purified by flash silica gel column chromatography to afford the target product 2-fluoropyridine-5-boronic acid pinacol ester (10.5 g, 82.85% yield). The structure of the product was confirmed by 1H NMR (400 MHz, chloroform-d): δ 8.59 (s, 1H), 8.15 (dt, J = 1.76, 8.41 Hz, 1H), 6.91 (dd, J = 2.26, 8.28 Hz, 1H), 1.35 (s, 12H). | | References | [1] Patent: EP3333157, 2018, A1. Location in patent: Paragraph 0255; 0256
[2] Patent: EP3239143, 2017, A2. Location in patent: Paragraph 0215
[3] Patent: WO2006/38116, 2006, A2. Location in patent: Page/Page column 40
[4] Patent: EP2891656, 2015, A1. Location in patent: Paragraph 0245
[5] Patent: WO2006/126081, 2006, A2. Location in patent: Page/Page column 52-53 |
| | 2-Fluoropyridine-5-boronic acid pinacol ester Preparation Products And Raw materials |
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