TYRPHOSTIN AG 538

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TYRPHOSTIN AG 538 manufacturers
TYRPHOSTIN AG 538 Basic information
Product Name:TYRPHOSTIN AG 538
Synonyms:AG 538 - CAS 133550-18-2 - Calbiochem;(αe)-α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile;AG 538, (αE)-α-[(3,4-Dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-benzenepropanenitrile;(E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile;Benzenepropanenitrile, α-[(3,4-dihydroxyphenyl)methylene]-3,4-dihydroxy-β-oxo-, (αE)-
CAS:133550-18-2
MF:C16H11NO5
MW:297.26
EINECS:
Product Categories:
Mol File:133550-18-2.mol
TYRPHOSTIN AG 538 Structure
TYRPHOSTIN AG 538 Chemical Properties
Boiling point 637.5±55.0 °C(Predicted)
density 1.538±0.06 g/cm3(Predicted)
storage temp. −20°C
solubility DMSO: 5mg/mL
form solid
pka7.48±0.35(Predicted)
color Light yellow to yellow
Safety Information
Safety Statements 22-24/25
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
TYRPHOSTIN AG 538 Usage And Synthesis
UsesAG 538 is a potent, competitive inhibitor of IGF-1 receptor kinase, with an IC50 of 400 nM[1].
DefinitionChEBI: 3-(3,4-dihydroxyphenyl)-2-[(3,4-dihydroxyphenyl)-oxomethyl]-2-propenenitrile is a member of chalcones.
Biological ActivityCell permeable: yes', 'Primary Target
IGF-1 receptor kinase', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 400 nM against IGF-1 receptor kinase
References[1] G Blum, et al. Substrate Competitive Inhibitors of IGF-1 Receptor Kinase. Biochemistry. 2000 Dec 26;39(51):15705-12. DOI:10.1021/bi001516y
TYRPHOSTIN AG 538 Preparation Products And Raw materials
Tag:TYRPHOSTIN AG 538(133550-18-2) Related Product Information
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