AZ7550 Mesylate
| 中文名称 | AZ7550 Mesylate |
|---|---|
| 中文同义词 | AZ7550甲磺酸盐;AZ7550 Mesylate 抑制剂;AZ7550 Mesylate 抑制剂 |
| 英文名称 | AZ7550 Mesylate |
| 英文同义词 | AZ7550 Mesylate;AZ7550 trimesylate salt;N-(4-Methoxy-2-(methyl(2-(methylamino)ethyl)amino)-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide trimethanesulfonate |
| CAS号 | 2319837-99-3 |
| 分子式 | C28H35N7O5S |
| 分子量 | 581.69 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2319837-99-3.mol |
| 结构式 |  |
AZ7550 Mesylate 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 浅黄至黄色 |
IC50: 1.6 μM (IGF1R), 88 nM (MLK1), 156 nM (ACK1), 195 nM (ErbB4), 228 nM (MNK2), 302 nM (FLT3), 420 nM (ALK ), 449 nM (FES), 840 nM (IRR), 843 nM (BRK), 977 nM (BLK), 995 nM (FAK), 1256 nM (Ins R), 1317 nM (TEC), 1784 nM (FLT4), 2288 nM (PYK2), 2443 nM (Txk), 5104 nM (BTK)
AZ7550 (Compound 28) appeares to offer a broadly similar potency and selectivity profile to the parent compound AZD9291. AZ7550 inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo with IC 50 s of 45, 26, and 786 nM, respectively. AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 with GI 50 s of 19, 15, and 537 nM, respectively.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-B0794BR | AZ7550 Mesylate AZ7550 Mesylate (Standard) | 2319837-99-3 | 1 mg | 2400元 |
| 2026/09/15 | HY-B0794BR | AZ7550 Mesylate AZ7550 Mesylate (Standard) | 2319837-99-3 | 5 mg | 6000元 |