(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid

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Company Name: Xianning Shen Lan Biomedical Research and Development Co., Ltd.  Gold
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Company Name: Shanghai Haozhixiang Biotechnology Co., Ltd  
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(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid manufacturers

  • PF-06679142
  • PF-06679142 pictures
  • $2380.00
  • 2026-07-27
  • CAS:1467059-66-0
  • Purity:
  • Supply Ability: 10g
(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid Basic information
Product Name:(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid
Synonyms:(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid;PF-06679142;1H-Indole-3-carboxylic acid, 4,6-difluoro-5-[4-[(2S)-tetrahydro-2H-pyran-2-yl]phenyl]-;PF 6679142;PF6679142;PF-6679142;4,6-difluoro-5-{4-[(2S)-oxan-2-yl]phenyl}-1H-indole-3-carboxylic acid;Compound T24622
CAS:1467059-66-0
MF:C20H17F2NO3
MW:357.35
EINECS:
Product Categories:
Mol File:1467059-66-0.mol
(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid Structure
(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid Chemical Properties
Boiling point 573.1±50.0 °C(Predicted)
density 1.372±0.06 g/cm3(Predicted)
pka2.00±0.30(Predicted)
InChIInChI=1S/C20H17F2NO3/c21-14-9-15-18(13(10-23-15)20(24)25)19(22)17(14)12-6-4-11(5-7-12)16-3-1-2-8-26-16/h4-7,9-10,16,23H,1-3,8H2,(H,24,25)/t16-/m0/s1
InChIKeyJQJNGAWEMYQJIQ-INIZCTEOSA-N
SMILESN1C2=C(C(F)=C(C3=CC=C([C@H]4OCCCC4)C=C3)C(F)=C2)C(C(O)=O)=C1
Safety Information
MSDS Information
(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid Usage And Synthesis
UsesPF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC50 of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research[1].
IC 50AMPK α1β1γ1: 22 nM (EC50)
References[1] Edmonds DJ, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22;61(6):2372-2383. DOI:10.1021/acs.jmedchem.7b01641
(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid Preparation Products And Raw materials
Tag:(S)-4,6-difluoro-5-(4-(tetrahydro-2H-pyran-2-yl)phenyl)-1H-indole-3-carboxylic acid(1467059-66-0) Related Product Information
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