3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-

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Products Intro: Product Name:CCG-222740
CAS:1922098-69-8
Purity:98.76% Package:5mg;59USD|10mg;101USD|25mg;191USD Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:CCG-222740
CAS:1922098-69-8
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Products Intro: Product Name:CCG-222740
CAS:1922098-69-8
Purity:98% HPLC Package:100mg，500mg，1g，5g，10g
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Products Intro: Product Name:CCG-222740
CAS:1922098-69-8
Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:N-(4-Chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide
CAS:1922098-69-8
Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing

3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- manufacturers

  • CCG-222740
  • CCG-222740 pictures
  • $59.00 / 5mg
  • 2026-03-13
  • CAS:1922098-69-8
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  • Purity: 98.79%
  • Supply Ability: 10g
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Basic information
Product Name:3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-
Synonyms:3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-;Rho-associated kinase,CCG222740,Rho-kinase,Rho,CCG-222740,CCG 222740,Inhibitor,inhibit,muscle,actin,factor,MRTF,transcription,ROK,metastasis,protein,Rho-associated protein kinase,myocardin-related,fibrosis,Ras,melanoma,orally,expression,ROCK,alpha-smooth;N-(4-Chlorophenyl)-5,5-difluoro-1-(3-(furan-2-yl)benzoyl)piperidine-3-carboxamide;CCG-222740, 10 mM in DMSO;CCG-222740 ，S6673
CAS:1922098-69-8
MF:C23H19ClF2N2O3
MW:444.86
EINECS:
Product Categories:
Mol File:1922098-69-8.mol
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Structure
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Chemical Properties
Boiling point 657.1±55.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:107.0(Max Conc. mg/mL);240.52(Max Conc. mM)
Ethanol:89.0(Max Conc. mg/mL);200.06(Max Conc. mM)
form Solid
pka13.69±0.70(Predicted)
color Light yellow to yellow
Safety Information
MSDS Information
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Usage And Synthesis
UsesCCG-222740 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor[1]. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis[2].
in vivo

CCG-222740 (oral gavage; 100 mg/kg/day for 7 days) significantly reduces α-SMA levels in the pancreas of caerulein-stimulated KC mice[1].

Animal Model:KC mice (LSL-KrasG12D/+; Pdx-1-Cre) of age at 9 weeks[1]
Dosage:100mg/kg
Administration:Oral gavage; daily; for 7 days
Result:Reduced α-SMA levels in the pancreas of caerulein-stimulated KC mice.
References[1] Leal AS, et al. The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in KrasG12D; Pdx1-Cre (KC) mice. Sci Rep. 2019 May 8;9(1):7072. DOI:10.1038/s41598-019-43430-0
[2] Yu-Wai-Man C, et al. Local delivery of novel MRTF/SRF inhibitors prevents scar tissue formation in a preclinical model of fibrosis. Sci Rep. 2017 Mar 31;7(1):518. DOI:10.1038/s41598-017-00212-w
3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]- Preparation Products And Raw materials
Tag:3-Piperidinecarboxamide, N-(4-chlorophenyl)-5,5-difluoro-1-[3-(2-furanyl)benzoyl]-(1922098-69-8) Related Product Information
CCT128930 CC-122 CCT 137690 CCG215022 CC-92480 CC-885 CCT245737 CCF-642