K-Ras G12C-IN-4

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Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:K-Ras G12C-IN-4
CAS:2376328-55-9
Purity:98.00% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
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Products Intro: Product Name:K-Ras G12C-IN-4
CAS:2376328-55-9
Purity:98% Package:$450.9/5mg;$745.9/10mg;$1525.9/25mg;Bulk package Remarks:98%
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
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Products Intro: Product Name:K-Ras G12C-IN-4
CAS:2376328-55-9
Purity:98% Package:10mg;100mg;1g;10g;100g;1kg Remarks:1g
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
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Products Intro: Product Name:K-Ras G12C-IN-4
CAS:2376328-55-9
Package:1ml Remarks:T97385
Company Name: Shanghai SuperLan Chemcial Technique Centre  
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Products Intro: Product Name:K-RAS G12C-IN-4
CAS:2376328-55-9
Purity:95 Package:1G,5G,10G,50G,100G,1KG
K-Ras G12C-IN-4 Basic information
Product Name:K-Ras G12C-IN-4
Synonyms:K-Ras G12C-IN-4;1H-Indole-1-acetamide, 5-chloro-2-cyclopropyl-3-[(3,4-dihydro-5-methoxy-2(1H)-isoquinolinyl)carbonyl]-7-methyl-N-[1-(1-oxo-2-propen-1-yl)-3-azetidinyl]-;Inhibitor,K Ras G12C IN 4,inhibit,Ras,K-Ras G-12C-IN-4,KRas G12CIN4;K-Ras G12C-IN-4, 10 mM in DMSO
CAS:2376328-55-9
MF:C31H33ClN4O4
MW:561.07
EINECS:
Product Categories:
Mol File:2376328-55-9.mol
K-Ras G12C-IN-4 Structure
K-Ras G12C-IN-4 Chemical Properties
storage temp. Store at -20°C
solubility DMSO : 62.5 mg/mL (111.39 mM; ultrasonic and warming and heat to 60°C)
form Solid
color White to off-white
Safety Information
MSDS Information
K-Ras G12C-IN-4 Usage And Synthesis
UsesK-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1].
Biological ActivityK-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C[1]. K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells[1].K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells[1].
References[1]. Shin Y, et al. Discovery of N-(1-Acryloylazetidin-3-yl)-2-(1H-indol-1-yl)acetamides as Covalent Inhibitors of KRASG12C. ACS Med Chem Lett. 2019 Aug 20;10(9):1302-1308.
K-Ras G12C-IN-4 Preparation Products And Raw materials
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