|
|
| Product Name: | eIF4E antibody | | Synonyms: | eIF4E antibody;Mouse Monoclonal EIF4E Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![eIF4E antibody Structure]() |
| | eIF4E antibody Chemical Properties |
| | eIF4E antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey;Mink;Zebrafish | | Background | Eukaryotic initiation factor 4E binds to the mRNA cap structure to mediate the initiation of translation. eIF4E interacts with eIF4G, a scaffold protein that promotes assembly of eIF4E and eIF4A into the eIF4F complex. eIF4B is thought to assist the eIF4F complex in translation initiation. Upon activation by mitogenic and/or stress stimuli mediated by Erk and p38 MAPK, Mnk1 phosphorylates eIF4E at Ser209 in vivo. Two Erk and p38 MAPK phosphorylation sites in mouse Mnk1 are essential for Mnk1 kinase activity. The carboxy-terminal region of eIF4G also contains serum-stimulated phosphorylation sites, including Ser1108, Ser1148, and Ser1192. Phosphorylation at these sites is blocked by the PI3 kinase inhibitor LY294002 and by the FRAP/mTOR inhibitor rapamycin. | | References | [1] Sonenberg, N. et al. (1978) Proc. Natl. Acad. Sci. USA 75, 4843-47.
[2] Gingras, A.C. et al. (1999) Annu. Rev. Biochem. 68, 913-63.
[3] Waskiewicz, A. et al. (1999) Mol. Cell. Biol. 19, 1871-80.
[4] Pyronnet, S. et al. (1999) EMBO J. 18, 270-9.
[5] Raught, B. et al. (2000) EMBO J. 19, 434-44. |
| | eIF4E antibody Preparation Products And Raw materials |
|