| Company Name: |
GeneTex, Inc. |
| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
international@genetex.com |
| Company Name: |
Enzo Biochem Inc |
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Email: |
Enzoname@qq.com |
|
| | FNIP1 antibody Chemical Properties |
| | FNIP1 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | FNIP1 and FNIP2 were identified as proteins interacting with tumor suppressor folliculin. FNIP1 and FNIP2 directly associate with AMPK, which indicates that they play roles in the energy and nutrient sensing pathways. Further studies show that the FLCN/FNIP2 complex functions as a GTPase-activating protein for Rag GTPase C and Rag GTPase D. The FLCN/FNIP2 complex thus promotes binding of mTORC1 to Rag heterodimers, leading to mTORC1 activation. In addition, along with FLCN, both FNIP1 and FNIP2 contribute to kidney tumor suppression. | | References | [1] Baba, M. et al. (2006) Proc Natl Acad Sci U S A 103, 15552-7.
[2] Hasumi, H. et al. (2008) Gene 415, 60-7.
[3] Takagi, Y. et al. (2008) Oncogene 27, 5339-47.
[4] Tsun, Z.Y. et al. (2013) Mol Cell 52, 495-505.
[5] Hasumi, H. et al. (2015) Proc Natl Acad Sci U S A 112, E1624-31. |
| | FNIP1 antibody Preparation Products And Raw materials |
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