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| Product Name: | FTH1 antibody | | Synonyms: | FTH1 antibody;Mouse Monoclonal FTH1 Antibody | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![FTH1 antibody Structure]() |
| | FTH1 antibody Chemical Properties |
| | FTH1 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat;Monkey | | Background | Ferritin is a ubiquitous and highly conserved protein that plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and bioavailable form. The assembled ferritin molecule, often referred to as a nanocage, can store up to 4,500 atoms of iron. It forms a holoenzyme of ~450 kDa, consisting of 24 subunits made up of two types of polypeptide chains: ferritin heavy chain and ferritin light chain, each having unique functions. FTHs catalyze the first step in iron storage, the oxidation of Fe(II), whereas FTLs promote the nucleation of ferrihydrite, enabling storage of Fe(III). In addition to iron buffering, FTH also enhances thymidine biosynthesis. Serum ferritin levels indicate the amount of iron stored in the body and is the most sensitive test for anemia. It is markedly elevated in inflammation, malignancy, and iron overload disorders. Research studies have found that defects in ferritin proteins are also associated with several neurodegenerative diseases. | | References | [1] Munro, H.N. et al. (1988) Ann N Y Acad Sci 526, 113-23.
[2] Theil, E.C. (2004) Annu Rev Nutr 24, 327-43.
[3] Theil, E.C. et al. (2006) J Biol Inorg Chem 11, 803-10.
[4] Treffry, A. et al. (1992) FEBS Lett 302, 108-12.
[5] Oppenheim, E.W. et al. (2001) J Biol Chem 276, 19855-61.
[6] Tarng, D.C. (2009) Nat Clin Pract Nephrol 5, 66-7.
[7] Fischer, P. et al. (1997) Life Sci 60, 2273-8. |
| | FTH1 antibody Preparation Products And Raw materials |
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