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| | JMJD1B (C6D12) Rabbit mAb Chemical Properties |
| | JMJD1B (C6D12) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Monkey | | Background | The methylation state of lysine residues in histone proteins is a major determinant of the formation of active and inactive regions of the genome and is crucial for the proper programming of the genome during development. Jumonji C domain-containing proteins represent the largest class of potential histone demethylase proteins. The JmjC domain of several proteins has been shown to catalyze the demethylation of mono-, di-, and tri-methyl lysine residues via an oxidative reaction that requires iron and α-ketoglutarate. Based on homology, both humans and mice contain at least 30 such proteins, which can be divided into seven separate families. The JMJD1 family, also known as JHDM2 family, contains four members: hairless, JMJD1A/JHDM2A, JMJD1B/JHDM2B, and JMJD1C/JHDM2C. Hairless is expressed in the skin and brain and acts as a co-repressor of the thyroid hormone receptor. Mutations in the hairless gene cause alopecia in both mice and humans. JMJD1A is expressed in meiotic and post-meiotic male germ cells, contributes to androgen receptor-mediated gene regulation, and is required for spermatogenesis. It has also been identified as a downstream target of OCT4 and STAT3 and is critical for the regulation of self-renewal in embryonic stem cells. JMJD1B is a more widely expressed family member and is frequently deleted in myeloid leukemia. JMJD1C is a co-factor of both the androgen and thyroid receptors and has a potential link to autism. Members of the JMJD1/JHDM2 family have been shown to demethylate mono-methyl and di-methyl histone H3. | | References | [1] Kubicek, S. et al. (2006) Ernst Schering Res Found Workshop , 1-27.
[2] Lin, W. and Dent, S.Y. (2006) Curr Opin Genet Dev 16, 137-42.
[3] Klose, R.J. et al. (2006) Nat Rev Genet 7, 715-27.
[4] Cachon-Gonzalez, M.B. et al. (1994) Proc Natl Acad Sci USA 91, 7717-21.
[5] Ahmad, W. et al. (1998) Science 279, 720-4.
[6] Potter, G.B. et al. (2001) Genes Dev 15, 2687-701.
[7] Höög, C. et al. (1991) Mol Reprod Dev 30, 173-81.
[8] Yamane, K. et al. (2006) Cell 125, 483-95.
[9] Okada, Y. et al. (2007) Nature 450, 119-123.
[10] Loh, Y.H. et al. (2007) Genes Dev 21, 2545-57.
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| | JMJD1B (C6D12) Rabbit mAb Preparation Products And Raw materials |
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