| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
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| Product Name: | CaCO2 | | Synonyms: | CaCO2;Caco-2 Cells Line;Caco-2/ATCC | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![CaCO2 Structure]() |
| | CaCO2 Chemical Properties |
| storage temp. | -196°C | | form | liquid | | biological source | human colon |
| WGK Germany | WGK 3 | | Storage Class | 10 - Combustible liquids |
| | CaCO2 Usage And Synthesis |
| Uses | CACO-2 has been used in the cytotoxicity studies with high pressure-assisted extraction (HPE) fraction of nettle leaf extracts.
CACO-2 may be used as a cell model to study:
- in vitro permeability assay with various biopharmaceuticals
- in iron uptake and absorption studies
- in the cytotoxicity assay with surfactants and transporter inhibitors
- in liposome formulated drug uptake and cytotoxicity studies
| | Biochem/physiol Actions | Caco-2 (Cancer coli-2) is derived from colorectal adenocarcinoma and grows as an adherent monolayer of epithelial cells. Caco-2 cell line is a widely used intestinal epithelium model and has unique spontaneous differentiation and confluence property. It actively transports vitamins, hormones, amino acids and sugars. Caco-2 expresses various enzymes, ionic and non-ionic transporters similar to normal human epithelia. Caco-2 cell line models grow on filter support. They have simplicity and reproducibility and provide reliable information. Since Caco-2 mimics the intestinal epithelium, it is the preferred cell model for cytotoxic studies, food and drug transport studies. |
| | CaCO2 Preparation Products And Raw materials |
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