AN11251 manufacturers
- AN11251
-
- $4160.00
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2026-05-22
- CAS:2130750-59-1
- Purity:
- Supply Ability: 10g
- AN11251
-
- $4160.00
-
2026-05-21
- CAS:2130750-59-1
- Purity:
- Supply Ability: 10g
- AN11251
-
- $6800.00
-
2025-08-22
- CAS:2130750-59-1
- Purity:
- Supply Ability: 10g
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| | AN11251 Basic information |
| Product Name: | AN11251 | | Synonyms: | AN11251;Acetic acid, 2-[(7-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)oxy]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester;AN-11251,AN11251;(3aR,4R,5R,7S,8S,9R,9aS,12R)-8-Hydroxy-4,7,9,12-tetramethyl-3-oxo-7-vinyldecahydro-4,9a-propanocyclopenta[8]annulen-5-yl 2-((7-fluor o-1-hydroxy-1,3-dihydrobenzo[C][1,2]-oxaborol-6-yl)oxy)acetate | | CAS: | 2130750-59-1 | | MF: | C29H38BFO7 | | MW: | 528.42 | | EINECS: | | | Product Categories: | | | Mol File: | 2130750-59-1.mol |  |
| | AN11251 Chemical Properties |
| | AN11251 Usage And Synthesis |
| Description | AN11251 is a potenet Anti-Wolbachia Agent with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis (EC50 = 1.5nM for LDW1 cell lines and 15 nM for C6/36 cell lines). AN11251 showed in vitro anti-Wolbachia activity and physicochemical and pharmacokinetic properties providing high exposure in plasma. | | Uses | AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines[1]. | | in vivo | AN11251 (25 mg/kg, PO, BID for 7 or 14 days) reduces the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively[1]. | Animal Model: | CB.17 SCID mice inoculated with 50 L3-stage B. malayi larvae[1]. | | Dosage: | 25 mg/kg. | | Administration: | Orally, BID for 7 or 14 days. | | Result: | Reduced the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively. |
| | References | [1] Jacobs RT, et al. Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis. J Med Chem. 2019 Mar 14;62(5):2521-2540. DOI:10.1021/acs.jmedchem.8b01854 |
| | AN11251 Preparation Products And Raw materials |
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