CPUY074020
| 中文名称 | CPUY074020 |
|---|---|
| 中文同义词 | 3-(1-哌啶基)-5-[[2-(1-吡咯烷基)乙基]氨基]-6H-蒽并[1,9-CD]异噁唑-6-酮;化合物 T10882;化合物CPUY074020;化合物CPUY074020,10 MM DMSO 溶液;CPUY074020,3-(1-哌啶基)-5-[[2-(1-吡咯烷基)乙基]氨基]-6H-蒽并[1,9-cd]异噁唑-6-酮 |
| 英文名称 | CPUY074020 |
| 英文同义词 | CPUY074020;3-(1-Piperidyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-6H-anthra[1,9-cd]isoxazol-6-one;6H-Anthra[1,9-cd]isoxazol-6-one, 3-(1-piperidinyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-;CPUY074020,CPUY-074020;CPUY074020, 10 mM in DMSO;3-(1-Piperidinyl)-5-[[2-(1-pyrrolidinyl)ethyl]amino]-6H-anthra[1,9-cd]isoxazol-6-one |
| CAS号 | 902279-44-1 |
| 分子式 | C25H28N4O2 |
| 分子量 | 416.52 |
| EINECS号 | |
| 相关类别 | 对照品 |
| Mol文件 | 902279-44-1.mol |
| 结构式 |  |
CPUY074020 性质
| 沸点 | 677.6±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.305±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 9.90±0.20(Predicted) |
| 形态 | Solid |
| 颜色 | Brown to dark brown |
CPUY074020 是一种高效、有口服活性的组蛋白甲基转移酶 G9a 抑制剂，其 IC50 值为 2.18 μM。CPUY074020 具有抗增殖活性。
IC50: 2.18 μM (G9a)
CPUY074020 (2-8μM; 24 hours) induces cell death through apoptosis.
CPUY074020 (2.5-10μM ; 48 hours) dose-dependently de-regulates H3K9 trimethylation.
Apoptosis Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 2 μM, 4 μM, 8 μM |
| Incubation Time: | 24 hours |
| Result: | Induced MCF-7 cells apoptosis. |
Western Blot Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 2.5 μM, 5 μM, 10 μM |
| Incubation Time: | 48 hours |
| Result: | Dose-dependently de-regulated H3K9 trimethylation. |
CPUY074020 exhibits reasonable PK properties, with an oral bioavailability of 55.5% and a T
1/2
value of 4.0 hours at an oral dose of 10 mg/kg.
| Animal Model: | Mice |
| Dosage: | 10 mg/kg |
| Administration: | Oral administration |
| Result: | t 1/2 =4.0 hours |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-100757 | CPUY074020 | 902279-44-1 | 1 mg | 550元 |
| 2026/06/05 | HY-100757 | CPUY074020 CPUY074020 | 902279-44-1 | 5 mg | 1240元 |