4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide

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Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:ALDH2 modulator 1
CAS:1629615-99-1
Purity:98.07% Package:1mg;97USD|5mg;293USD|10mg;463USD
Company Name: Shanghai Hanhong Scientific Co., Ltd.
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Products Intro: Product Name:4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide
CAS:1629615-99-1
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Company Name: Shanghai CR Corporation Limited  
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Products Intro: Product Name:ALDH2 modulator
CAS:1629615-99-1
Purity:95+
Company Name: Suzhou Haiben Pharmaceutical Co., Ltd  
Tel: 19353112242
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Products Intro: Product Name:4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide
CAS:1629615-99-1
Purity:98%+ Package:1g；5g；10g；100g; 1kg
Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
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Products Intro: Product Name:ALDH2 modulator 1
CAS:1629615-99-1
Purity:98.00% Package:1mg;5mg;10mg

4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide manufacturers

  • ALDH2 modulator 1
  • ALDH2 modulator 1 pictures
  • $41.00 / 1mg
  • 2026-01-05
  • CAS:1629615-99-1
  • Min. Order:
  • Purity: 99.87%
  • Supply Ability: 10g
4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide Basic information
Product Name:4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide
Synonyms:4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide;3-Pyridinecarboxamide, 4-chloro-2-(cyclopropylmethoxy)-N-[(3-fluoro-4-methoxyphenyl)methyl]-;ALDH2 modulator 1;ALDH2 modulator 1, 10 mM in DMSO;ALDH2 modulator
CAS:1629615-99-1
MF:C18H18ClFN2O3
MW:364.8
EINECS:
Product Categories:
Mol File:1629615-99-1.mol
4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide Structure
4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide Chemical Properties
Boiling point 505.5±50.0 °C(Predicted)
density 1.316±0.06 g/cm3(Predicted)
pka12.54±0.46(Predicted)
Safety Information
MSDS Information
4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide Usage And Synthesis
UsesALDH2 modulator 1 is a potent and orally active aldehyde dehydrogenase-2 (ALDH2) modulator. ALDH2 modulator 1 reduces blood alcohol levels in mice[1].
in vivo

ALDH2 modulator 1 (compound 161) (10 mg/kg for i.v.; 40, 60 mg/kg for p.o.) reduces blood alcohol levels in mice treated with PO 5 g/kg of EtOH[1].

Animal Model:8-9 weeks, 20-22 g, Male C57BL6 mice (treated with PO 5/kg of EtOH)[1]
Dosage:40, 60 mg/kg for p.o. or 10 mg/kg for i.v.
Administration:P.o. or i.v.
Result:Reduced blood alcohol levels in mice treated with PO 5 g/kg of EtOH.
IC 50ALDH2
References[1] Wenjin Yang, et al. Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof. WO2014160185A2.
4-Chloro-2-(cyclopropylmethoxy)-N-(3-fluoro-4-methoxybenzyl)nicotinamide Preparation Products And Raw materials
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