2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl-

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2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl- Suppliers list
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2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl- manufacturers

  • MARK-IN-2
  • MARK-IN-2 pictures
  • $2120.00
  • 2026-07-27
  • CAS:1314893-26-9
  • Purity:
  • Supply Ability: 10g
  • MARK-IN-2
  • MARK-IN-2 pictures
  • $2120.00
  • 2026-07-27
  • CAS:1314893-26-9
  • Purity:
  • Supply Ability: 10g
  • MARK-IN-2
  • MARK-IN-2 pictures
  • $2120.00
  • 2025-07-17
  • CAS:1314893-26-9
  • Purity:
  • Supply Ability: 10g
2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl- Basic information
Product Name:2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl-
Synonyms:2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl-;MARK-IN-2;MARK IN 2,MARKIN2
CAS:1314893-26-9
MF:C18H18ClF2N5OS
MW:425.88
EINECS:
Product Categories:
Mol File:1314893-26-9.mol
2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl- Structure
2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl- Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl- Usage And Synthesis
Description

MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 5 nM.

MARK-IN-2 (Compound 27) is a potent MARK inhibitor. Inhibition of MARK represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease. MARK-IN-2 inhibits MARK3 with an IC50 of 5 nM. MARK-IN-2 also inhibits MARK3 in primary cell culture of rat cortical neurons with an IC50 of 280 nM[1].

Characterization of the i.v. pharmacokinetic properties of MARK-IN-2 in rat and dog reveals reasonable volumes of distribution but moderate to high clearance and short half-lives. MARK-IN-2 (Compound 27) has moderate terminal elimination half-life (t1/2=0.7 h, and 1 h for rat and dog) [1].

UsesMARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 5 nM.
in vivo

Characterization of the i.v. pharmacokinetic properties of MARK-IN-2 in rat and dog reveals reasonable volumes of distribution but moderate to high clearance and short half-lives. MARK-IN-2 (Compound 27) has moderate terminal elimination half-life (t1/2=0.7 h, and 1 h for rat and dog) [1].

References

[1]. Sloman DL, et al. Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4362-6.

2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl- Preparation Products And Raw materials
Tag:2-Thiophenecarboxamide, N-[(1R,6R)-6-amino-2,2-difluorocyclohexyl]-4-(6-chloropyrazolo[1,5-a]pyrimidin-3-yl)-5-methyl-(1314893-26-9) Related Product Information
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