| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Resolvin E4
CAS:1781227-87-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Resolvin E4
CAS:1781227-87-9
Purity:95% Package:10μg;25μg;50μg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Resolvin E4
CAS:1781227-87-9
Package:10μg/RMB 2970
|
Resolvin E4 manufacturers
- Resolvin E4
-
- $429.00 / 10μg
-
2026-03-12
- CAS:1781227-87-9
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Resolvin E4 Basic information |
| Product Name: | Resolvin E4 | | Synonyms: | Resolvin E4;Resolvin E4,Resolvin E-4;6,8,11,13,17-Eicosapentaenoic acid, 5,15-dihydroxy-, (5S,6E,8Z,11Z,13E,15S,17Z)- | | CAS: | 1781227-87-9 | | MF: | C20H30O4 | | MW: | 334.45 | | EINECS: | | | Product Categories: | | | Mol File: | 1781227-87-9.mol |  |
| | Resolvin E4 Chemical Properties |
| Boiling point | 538.7±50.0 °C(Predicted) | | density | 1.054±0.06 g/cm3(Predicted) | | storage temp. | Store at -80°C | | solubility | DMF: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 0.05 mg/ml | | pka | 4.67±0.10(Predicted) |
| | Resolvin E4 Usage And Synthesis |
| Uses | Resolvin E4 (RvE4) is an endogenous metabolite that stimulates efferocytosis of apoptotic neutrophils and senescent erythrocytes. Resolvin E4 enhances resolution of hemorrhagic exudates and inflammation in vivo[1]. | | Biological Activity | Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1 It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO) via 15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE intermediates in vitro and by isolated human M2 macrophages or polymorphonuclear (PMN) neutrophils under normoxic or hypoxic conditions. RvE4 synthesis is enhanced in M2 macrophage and neutrophil co-cultures, indicating transcellular biosynthesis by a potential 15-LO and 5-LO mechanism. It has been found in mouse inflammatory exudates. RvE4 (10 nM) increases efferocytosis of apoptotic neutrophils or senescent red blood cells (sRBCs) by human M2 macrophages under hypoxic conditions in vitro. Intraperitoneal administration of RvE4 (100 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of hemorrhagic peritonitis induced by zymosan A and thrombin. It also increases inflammatory exudate macrophage infiltration and efferocytosis of apoptotic neutrophils and/or RBCs in the same model. | | References | 1.Norris, P.C., Libreros, S., and Serhan, C.N.Resolution metabolomes activated by hypoxic environmentSci. Adv.5(10)eaax4895(2019) |
| | Resolvin E4 Preparation Products And Raw materials |
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